Using nebulized tranexamic acid to reduce blood loss in sinus surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of preoperative administration of tranexamic acid, either intravenously or nebulized, on patients undergoing functional endoscopic sinus surgery (FESS). The primary focus is to assess the Modena Bleeding Score to evaluate the surgical field and blood loss during the procedure. Secondary outcomes include monitoring patient hemodynamics, anesthetic consumption, and any postoperative complications related to tranexamic acid. The study aims to improve surgical visibility and reduce complications associated with excessive bleeding during FESS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Either sex
2. age 18-65 years
3. ASA I-II who are listed for elective functional endoscopic sinus surgery (FESS) under general anesthesia
4. normal accepted coagulation profile and hematocrit value ≥30

Exclusion Criteria:

* • chronic renal failure

  * liver cirrhosis
  * bleeding disorders
  * current anticoagulant therapy
  * pregnancy or breastfeeding
  * impaired color vision
  * severe vascular ischemia
  * history of venous thrombosis, pulmonary embolism
  * long term treatment with acetylsalicylic acid or non-steroidal anti-inflammatory drugs not discontinued before surgery
  * hemoglobin (HB) concentration \<10 mg/dl \_allergy to TXA.
  * BMI \> 35 kg/ m2

Where it's running

• Main building, Assiut University Hospitals
  Asyut, Egypt Recruiting

Study contacts

• Study coordinator: Asmaa Shabaan Zanaty, Doctor
• Email: asmaa10557@gmail.com
• Phone: +201029505921

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.