Using multiple biomarkers to assess acute chest pain
Prognostic Value of Cardiovascular Risk of sST2, suPAR and High-sensitivity Troponin I in Patients With Acute Chest Pain
This study is testing if using multiple blood markers can help doctors better tell if chest pain is caused by a heart problem or something else in patients who come to the emergency room.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Roma) |
| Trial ID | NCT06295978 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients presenting with chest pain in the emergency department, aiming to improve the diagnosis of acute myocardial infarction and other cardiovascular conditions. It employs a multimarker approach, utilizing biomarkers such as sST2 and suPAR to enhance diagnostic accuracy beyond traditional methods like ECG. The study seeks to differentiate between cardiac and non-cardiac causes of chest pain, addressing the challenges faced by emergency physicians in making timely and accurate diagnoses.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who present to the emergency department with chest pain of uncertain cardiac origin and have non-diagnostic ECG results.
Not a fit: Patients with known cardiovascular diseases, acute coronary syndrome, or conditions that elevate biomarkers unrelated to cardiac causes may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate diagnoses and better management of patients with acute chest pain, potentially reducing morbidity and mortality.
How similar studies have performed: Other studies have shown promise in using multimarker approaches for cardiovascular diagnosis, indicating potential for success in this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years; * Patients who came to the emergency department with chest pain of presumable cardiac origin and uncertain etiologic diagnosis * ECG not diagnostic for ischemia * cTnI ultra within limits Exclusion Criteria: * STEMI * Sepsis and viral infections * Patients with ECG abnormalities that make it uninterpretable for ischemic purposes * Patients with previous coronary events * History of heart failure * Known diagnosis of cardiovascular disease, acute or chronic, including pericarditis, myocarditis * Conditions involving increases in sST2 and suPAR unrelated to cardiac causes, especially acute/chronic inflammatory or fibrotic conditions (inflammatory bowel disease, neoplasms, moderate-to-severe pulmonary fibrosis, chronic hepatopathy; autoimmune diseases)
Where this trial is running
Roma
- Fondazione Policlinico Universitario "A. Gemelli" IRCCS — Roma, Italy (Recruiting)
Study contacts
- Study coordinator: Andrea Piccioni, Dr.
- Email: andrea.piccioni@policlinicogemelli.it
- Phone: 0630153161
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.