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Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Using multifrequency MRE to evaluate kidney fibrosis in chronic kidney disease

Official title: Multifrequency Renal MR Elastography in Evaluation of Chronic Kidney Diseases: Can Shear Stiffness Evaluate Renal Fibrosis in GFR-normal Patients?

Run by Shengjing Hospital · NCT06202235 · Data updated 2026-11-12

This study is testing a new way to see how much scarring is in the kidneys of people with chronic kidney disease using special MRI scans, to help understand how the disease is progressing.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment200 (estimated)
SponsorShengjing Hospital
Academic / other
Locations1 site (Shenyang, Liaoning)
StatusRecruiting
StartedOctober 10, 2022
Main results expectedJune 8, 2027
Study endsJune 8, 2027
Registry record updatedFebruary 10, 2026
Trial IDNCT06202235 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include CKD patients aged 18-65 who are hospitalized for renal biopsy and have undergone renal MRI.

Probably not a fit

Patients with acute exacerbations of CKD, severe claustrophobia, or those who cannot tolerate MRE may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with chronic kidney disease (CKD) to assess kidney fibrosis using multifrequency Magnetic Resonance Elastography (MRE). The study aims to provide a noninvasive method for evaluating the extent of fibrosis, which is crucial for understanding CKD progression and its clinical implications. By analyzing patients at various stages of CKD, the research seeks to enhance the understanding of kidney fibrosis and its relationship to patient outcomes. The study will involve renal MRI scans conducted shortly before kidney biopsies to correlate MRE findings with histopathological results.

Why it matters

Potential benefit: If successful, this study could provide a safer, noninvasive method for assessing kidney fibrosis, potentially improving patient management and outcomes in CKD.

How similar studies have gone: While the use of MRE for assessing kidney fibrosis is gaining interest, this specific multifrequency approach is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

(1) adults with CKD defined according to the 2024 KDIGO guidelines, with either elevated SCr or abnormal proteinuria ; and (2) renal MRI was performed within 7 days of the renal biopsy.

Exclusion criteria:

(1) genitourinary malignancy, polycystic kidney disease, renal transplantation, or acute renal failure; (2) contraindications for MRI examination; (3) poor image quality; (4) kidney deformity or severe hydronephrosis on MRI; and (5) poorly defined corticomedullary demarcation.

Where it's running

  • Shengjing Hospital of China Medical University
    Shenyang, Liaoning, China     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Chronic Kidney Disease (CKD) 9Shengjing Hospital 40
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.