Using MRI to visualize cranial nerves for surgery on skull base tumors
Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy
This study is testing a new MRI technique to help doctors see cranial nerves better during surgery for skull base tumors, aiming to improve safety and outcomes for adult patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT02978911 on ClinicalTrials.gov |
What this trial studies
This study focuses on improving surgical outcomes for patients with skull base tumors by utilizing advanced diffusion tensor imaging (DTI) to create cranial nerve tractography. Preoperative cerebral MRI scans will be performed on adult patients with skull base tumors to visualize the displacement of cranial nerves, which can help surgeons avoid damaging these critical structures during surgery. The study employs a 3 tesla MRI machine to acquire detailed imaging data, which is then processed to track cranial nerve fibers probabilistically. This innovative approach aims to enhance surgical planning and patient safety.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients diagnosed with a skull base tumor that requires surgical removal.
Not a fit: Patients who are under 18 years old or pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of cranial nerve damage during surgery, leading to better patient outcomes.
How similar studies have performed: While the use of DTI and tractography is gaining traction, this specific application for cranial nerve visualization in skull base tumor surgery is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who present a skull base tumor that requires surgical removal * Patients adult, informed and agreed Exclusion Criteria: * Pregnant women * Patients under 18 years old, unable to legally consent
Where this trial is running
Bron
- Service de Neurologie B, Hôpital Neurologique, HCL — Bron, France (Recruiting)
Study contacts
- Principal investigator: Timothée Jacquesson, MD — Hospices Civils de Lyon
- Study coordinator: Timothée Jacquesson, MD
- Email: timothee.jacquesson@neurochirurgie.fr
- Phone: 472356921
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.