Using MRI to predict outcomes in cervical spinal cord compression
Quantitative Magnetic Resonance Imaging Parameters as Predictors of Outcome for Non-Myelopathic Degenerative Cervical Cord Compression: A Longitudinal Study
Masaryk University · NCT06094166
This study is testing if certain MRI measurements can help predict if people with cervical spinal cord compression will develop more serious symptoms over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 160 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Masaryk University (other) |
| Locations | 1 site (Brno) |
| Trial ID | NCT06094166 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify quantitative MRI parameters that can predict the progression of non-myelopathic degenerative cervical cord compression into symptomatic degenerative cervical myelopathy. It employs semi-automated detection of anatomical metrics and advanced imaging techniques, including diffusion-weighted MRI and magnetic resonance spectroscopy, to assess the severity and natural course of cervical spinal cord compression. The study will evaluate the correlation between these imaging metrics and clinical outcomes over time, providing insights into the disease's progression.
Who should consider this trial
Good fit: Ideal candidates include individuals with clinically asymptomatic cervical spinal cord compression or those without spinal cord compression who are eligible for MRI.
Not a fit: Patients with contraindications to MRI, such as those with implanted metal devices or pregnancy, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved predictive tools for identifying patients at risk of developing symptomatic degenerative cervical myelopathy.
How similar studies have performed: While similar studies have explored MRI metrics in spinal conditions, this specific approach utilizing semi-automated detection and advanced imaging techniques is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Subject with no contraindication to MR examination. Clinically asymptomatic cervical spinal cord compression or subjects with no spinal cord compression. Exclusion Criteria: * A subject will be excluded if he/she has a contraindication to MR scanning implanted metal clips or wires of the type which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field. * Pregnancy * Claustrophobia
Where this trial is running
Brno
- Faculty of Medicine, Masaryk University, Brno — Brno, Czechia (RECRUITING)
Study contacts
- Principal investigator: Josef Bednarik, Prof. MD. — Masaryk University
- Study coordinator: Tomas Horak, MD. PhD.
- Email: horak.tomas@fnbrno.cz
- Phone: +420724273734
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Degenerative Cervical Spinal Myelopathy, Cervical Spinal Cord Compression