Using MRI to assess fertility-sparing treatment for cervical cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the role of MRI, including diffusion-weighted imaging (DWI), in staging and evaluating the response to fertility-sparing treatments for early-stage cervical cancer. It focuses on patients desiring to preserve their fertility while undergoing treatments such as radical trachelectomy or cold knife conization. The study aims to identify risk factors for aggressive disease and assess the effectiveness of these treatments through pre- and post-treatment MRI evaluations. The research is conducted at the Oncological Gynecology Unit of Fondazione Policlinico Universitario Agostino Gemelli.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with cervical cancer FIGO stage up to IB2-IIA1 (T size \< 4 cm) wishing to preserve fertility treated at the Oncological Gynecology Unit of Foundation Policlinico Universitario Agostino Gemelli.
* absence of nodal disease,
* no menopausal status
* wish to preserve fertility
* refusal of radical treatment.
* Patients who had a pre-treatment and post-treatment magnetic resonance imaging.
* Availability of digital MR images and histopathological samples.

Exclusion Criteria:

* Patients aged under 18 years.
* Neuroendocrine cervical tumours or other rare histology, such as glassy cells or clear cell carcinoma non-HPV related adenocarcinoma.
* ongoing pregnancy at the time of diagnosis.
* Patients without available MR images on digital media or with low quality images.

Where it's running

• Advanced Radiology Center- Fondazione Policlinico Universitario A. Gemelli IRCCS
  Rome, Italy Recruiting

Study contacts

• Principal investigator: Benedetta Gui — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Benedetta Gui
• Email: benedetta.gui@policlinicogemelli.it
• Phone: +390630158637

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.