Using MR-guidance in Chemoradiotherapy for Cervical Cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the use of MR-guided radiation therapy in conjunction with concurrent chemoradiotherapy for patients with locally advanced cervical cancer. It aims to adapt treatment plans in real-time based on daily imaging to improve targeting of the tumor while minimizing damage to surrounding organs. The study will enroll 40 patients and assess early bowel and bladder toxicity as the primary endpoint, along with secondary outcomes such as tumor control and quality of life. The approach leverages advanced imaging techniques to enhance treatment precision and patient safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* biopsy-proven cervical cancer including squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma
* FIGO stage IB, IIA, IIB, IIIA, IIIB, IIIC1
* indication and eligibility for definitive chemoradiotherapy including brachytherapy discussed in an interdisciplinary tumor board
* Karnofsky performance score ≥ 70%
* 18-80 years of age
* Capacity of the patient to consent to participation in the study

Exclusion Criteria:

* FIGO stage IIIC2 and IV
* Paraaortic lymphatic node metastases
* small cell neuroendocrine cancer, melanoma and other rare cancers of the cervix
* previous radiotherapy of the pelvic region
* previous total or partial hysterectomy
* neoadjuvant chemotherapy
* contraindications against performing contrast-enhanced MRI scans (pacemakers, other implants making MRI impossible, allergy to gadolinium (GD)-based contrast agent)
* claustrophobia
* pregnant or lactating women
* other primary malignancies within 5 years before except carcinoma in situ of the cervix and basal cell carcinoma of the skin
* patient is enrolled in another study, that could influence the outcome of the presented study

Where it's running

• University Hospital of Heidelberg, Radiation Oncology
  Heidelberg, Germany Recruiting

Study contacts

• Study coordinator: Juliane Hörner-Rieber, MD
• Email: Juliane.hoerner-rieber@med.uni-heidelbeg.de
• Phone: +496221 56

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.