Using mouthwash with chlorhexidine and hyaluronic acid to improve healing after wisdom tooth surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of two different mouthwashes containing chlorhexidine, with and without hyaluronic acid, on the healing of surgical wounds following third molar surgery. Patients will be randomly assigned to one of three groups: one receiving the chlorhexidine plus hyaluronic acid mouthwash, another receiving chlorhexidine alone, and a control group receiving a placebo. The healing process will be monitored through photographs and a Wound Healing Index at multiple time points post-surgery. The study aims to determine if the addition of hyaluronic acid enhances wound healing compared to chlorhexidine alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* males or females of age range between 18 and 70 years,
* good health status,
* indication to perform third molar surgery,
* patients willing to give informed consent,
* compliance to the study follow-up,

Exclusion Criteria:

* pregnancy or breast-feeding,
* indication to antibiotic therapy prior to surgical treatment,
* chronic infections,
* systemic diseases (including cardiovascular, pulmonary, cerebral, and metabolic diseases),
* previous therapy with the mouth rinses employed in the present study, and
* smoking habit (\>20 cigarettes per day, and/or pipe or cigar smoking).

Where it's running

• University Hospital of Pisa
  Pisa, Italy Recruiting

Study contacts

• Study coordinator: Filippo Graziani
• Email: filippograziani@med.unipi.it
• Phone: +39050992772

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.