Using mouthwash with chlorhexidine and hyaluronic acid to improve healing after wisdom tooth surgery
Evaluation of Chlorhexidine Plus Hyaluronic Acid Mouthwash in Surgical Wound Healing Following Third Molar Surgery (CLOR_4)
This study is testing if a mouthwash with hyaluronic acid helps people heal better after getting their wisdom teeth removed compared to a mouthwash without it.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 54 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | University of Pisa Academic / other |
| Locations | 1 site (Pisa) |
| Trial ID | NCT05414253 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two different mouthwashes containing chlorhexidine, with and without hyaluronic acid, on the healing of surgical wounds following third molar surgery. Patients will be randomly assigned to one of three groups: one receiving the chlorhexidine plus hyaluronic acid mouthwash, another receiving chlorhexidine alone, and a control group receiving a placebo. The healing process will be monitored through photographs and a Wound Healing Index at multiple time points post-surgery. The study aims to determine if the addition of hyaluronic acid enhances wound healing compared to chlorhexidine alone.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18 to 70 who require third molar surgery and can provide informed consent.
Not a fit: Patients who are pregnant, have chronic infections, systemic diseases, or are heavy smokers may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved healing outcomes for patients undergoing third molar surgery.
How similar studies have performed: Previous studies have shown promising results with chlorhexidine in wound healing, but the combination with hyaluronic acid is a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * males or females of age range between 18 and 70 years, * good health status, * indication to perform third molar surgery, * patients willing to give informed consent, * compliance to the study follow-up, Exclusion Criteria: * pregnancy or breast-feeding, * indication to antibiotic therapy prior to surgical treatment, * chronic infections, * systemic diseases (including cardiovascular, pulmonary, cerebral, and metabolic diseases), * previous therapy with the mouth rinses employed in the present study, and * smoking habit (\>20 cigarettes per day, and/or pipe or cigar smoking).
Where this trial is running
Pisa
- University Hospital of Pisa — Pisa, Italy (Recruiting)
Study contacts
- Study coordinator: Filippo Graziani
- Email: filippograziani@med.unipi.it
- Phone: +39050992772
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.