Using mobile video to help young heart transplant patients take their medications
Official title: Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients: Enhancing Technological Innovation and Strengthening the Role of Small Businesses in Meeting Needs of Adolescent Organ Transplant
Run by University of Florida · NCT05732779 · Data updated 2026-11-12
This study tests whether using mobile videos can help young heart transplant patients remember to take their medications regularly.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 10 Years to 21 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Florida Academic / other |
| Locations | 4 sites (Coral Gables, Florida and 3 other locations) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | February 1, 2027 |
| Study ends | May 1, 2027 |
| Registry record updated | July 16, 2026 |
| Trial ID | NCT05732779 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adolescents aged 10-21 who have received a heart transplant and are capable of using a mobile app for medication management.
✕Probably not a fit
Patients with cognitive impairments that prevent them from providing informed assent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of a mobile video directly observed therapy (DOT) intervention aimed at improving medication adherence among adolescent heart transplant recipients. The study will randomly assign participants to receive the DOT intervention, which leverages technology to monitor and encourage adherence to immunosuppression medications. Given the high rates of non-adherence in this population, the trial seeks to address the challenges faced by youth in managing their complex post-transplant medication regimens. By promoting adherence, the study aims to reduce the risk of late acute rejection episodes and improve overall patient and graft outcomes.
Why it matters
Potential benefit: If successful, this intervention could significantly enhance medication adherence, leading to better health outcomes and reduced complications for adolescent heart transplant recipients.
How similar studies have gone: While there have been few successful interventions targeting medication adherence in this specific population, the use of technology in healthcare has shown promise in other settings, making this approach innovative yet somewhat untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligible participants are 10-21 years of age * Have received a heart transplant and are followed participating pediatric heart transplant centers * English-speaking or Spanish-speaking * Own a smart-phone or have access to the mobile app through other devices * Are willing to receive information through it * Have a MLVI score of greater than 2.0 over the last year Exclusion Criteria: • Those with cognitive impairments will not be eligible for enrollment due to inability to provide informed assent
Where it's running
-
University of Miami, Miller School of Medicine
Coral Gables, Florida, United States Recruiting -
University of Florida
Gainesville, Florida, United States Recruiting -
Joe DiMaggio Children's Hospital
Hollywood, Florida, United States Recruiting -
FSU College of Medicine
Tallahassee, Florida, United States Not yet recruiting
Study contacts
- Principal investigator: Dipankar Gupta, MD — University of Florida
- Study coordinator: Dipankar Gupta, MD
- Email: dgupta@ufl.edu
- Phone: 352-273-5422
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.