Using micro-osteoperforations to improve orthodontic treatment in patients with severe gum disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of micro-osteoperforations (MOPs) on orthodontic tooth movement in patients suffering from stage IV periodontitis. It is a randomized controlled trial with two groups: one receiving orthodontic treatment with MOPs and the other receiving the same treatment without MOPs. The study aims to assess changes in clinical attachment level (CAL) over a 12-month period following the placement of orthodontic appliances. Participants must have specific dental conditions, including flared teeth and intrabony defects, to qualify for the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients will be included if agreeing to undertake combined periodontal and orthodontic therapy following the clinical practice guideline of stage IV periodontitis patients, and fulfilling the following criteria:

* adult patients older than 18-year-old;
* systemically healthy (see exclusion criteria);
* diagnosed as stage IV (Papapanou et al., 2018) case-type 2 (Herrera et al. 2022) periodontitis;
* the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component \<5mm) (experimental teeth);
* in need of orthodontic therapy.

Exclusion Criteria:

* systemic diseases (diabetes mellitus, obesity, cardiovascular diseases);
* any medication that could affect the level of inflammation, (such as chronic antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers);
* pregnant or lactating woman;
* inability to respond questions or to attend follow-up visits;
* extreme skeletal malocclusions requiring orthognathic surgery;
* patients smoking more than 10 cigarettes/day; and
* the presence of PD greater or equal to 5mm with BOP after step 3 of periodontal therapy

Where it's running

• Faculty of Odontology, University Complutense Madrid
  Madrid, Madrid, Spain Recruiting

Study contacts

• Principal investigator: Conchita Martin, Prof — Universidad Complutense de Madrid
• Study coordinator: Conchita Martin, Prof
• Email: mariacom@ucm.es
• Phone: +343941901

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.