Using Metoclopramide to Improve Ovarian Response in IVF Patients
Official title: Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients: a Randomised, Double-blind, Placebo-controlled Trial
Run by Barzilai Medical Center · NCT03560583 · Data updated 2026-11-12
This study is testing if the medication metoclopramide can help women who have trouble responding to IVF treatments produce more eggs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 54 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Barzilai Medical Center Academic / other |
| Locations | 1 site (Ashkelon, Ashkelon District) |
| Status | Recruiting |
| Started | May 5, 2021 |
| Main results expected | December 2027 |
| Study ends | July 2028 |
| Registry record updated | February 10, 2025 |
| Trial ID | NCT03560583 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women classified as poor responders in IVF according to the Bologna criteria.
✕Probably not a fit
Patients with allergies to metoclopramide, prolactinemia, or those treated with dopamine agonists may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the efficacy of metoclopramide in patients undergoing in vitro fertilization (IVF) who are classified as poor responders according to the Bologna criteria. The study aims to determine whether metoclopramide, an antiemetic that blocks dopamine receptors, can enhance ovarian sensitivity to gonadotropins during controlled ovarian stimulation. Participants will receive either metoclopramide or a placebo to assess its impact on oocyte retrieval rates. The trial addresses a significant challenge in reproductive medicine, as no effective protocol has been established for this subgroup of IVF patients.
Why it matters
Potential benefit: If successful, this approach could improve ovarian response and increase the chances of successful IVF outcomes for patients with poor ovarian response.
How similar studies have gone: While this approach is novel for poor responders in IVF, similar studies using metoclopramide in other contexts have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Poor response according to "Bologna criteria" Exclusion Criteria: * Allergy to metoclopramide * Prolactinemia * Women treated with dopamine agonists
Where it's running
-
Barzilai University Medical Center
Ashkelon, Ashkelon District, Israel Recruiting
Study contacts
- Principal investigator: Leon Grin, MD — Barzilai Medical Center
- Study coordinator: Leon Grin, MD
- Email: leonti.grin@gmail.com
- Phone: 972-50-5999379
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.