Using Methylphenidate to Treat Adults with ADHD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of Methylphenidate (MPH), a common treatment for adults with Attention-Deficit/Hyperactivity Disorder (ADHD). It aims to identify clinical and genetic factors that predict how well patients respond to MPH, given the variability in treatment outcomes. Participants will receive immediate-release MPH while researchers will monitor their responses and tolerability. The study seeks to enhance understanding of personalized treatment approaches for ADHD in adults.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* White Brazilian of European descent
* Fulfillment of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, (DSM-IV) diagnostic criteria for ADHD
* Eligibility to immediate-release MPH (IR-MPH) treatment

Exclusion Criteria:

* Contraindication for IR-MPH use
* Current stimulant treatment
* Evidence of a clinically significant neurological disease that might affect cognition (e.g., delirium, dementia, epilepsy, head trauma, and multiple sclerosis)
* Current or past history of psychosis
* Estimated intelligence quotient score lower than 70

Where it's running

• Program on Attention-Deficit/Hyperactivity Disorder (PRODAH); Hospital de Clínicas de Porto Alegre
  Porto Alegre, Rio Grande do Sul, Brazil Recruiting

Study contacts

• Principal investigator: Eugênio H Grevet, MD, PhD — Hospital de Clinicas de Porto Alegre
• Study coordinator: Eugênio H Grevet, MD, PhD
• Email: ehgrevet@gmail.com
• Phone: +55 51 3359-8094

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Examining the link between motor skills and sensory processing in children aged 4 to 11

  This study looks at how motor skills and sensory processing are connected in children aged 4 to 11, including those with conditions like Autism, ADHD, and Developmental Coordination Disorder.

  Recruiting University of Vic - Central University of Catalonia · Vic · NCT06764810

• Digital therapy using neurofeedback for treating ADHD in children

  This study is testing a new iPad game that uses neurofeedback and executive function training to see if it can help children aged 6 to 12 with ADHD improve their attention and thinking skills.

  Recruiting at 2 sites Changhai Hospital · Shanghai, Shanghai Municipality and 1 other locations · NCT06369714

• Comparing Lisdexamphetamine and Methylphenidate for Kids with ADHD and Type 1 Diabetes

  This study is testing whether two different medications can help kids aged 8 to 16 with both ADHD and Type 1 Diabetes feel better and manage their symptoms more effectively.

  Recruiting Phase 2 Medical University of Lodz · Lodz, Łódź Voivodeship · NCT05957055

• Neurodevelopmental disorders in youth with criminal behavior

  This study looks at whether young people who commit crimes have neurodevelopmental disorders like ADHD or autism, and how these conditions relate to the crimes they commit.

  Recruiting National Taiwan University Hospital · Taipei · NCT05875363

• Home-based brain stimulation for treating ADHD

  This study tests whether a home-based brain stimulation treatment can help people with ADHD feel better and improve their focus over four weeks.

  Recruiting Massachusetts General Hospital · Charlestown, Massachusetts · NCT05354232

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.