Using methadone to prevent pain after orthopedic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of intraoperative methadone administration for managing postoperative pain in patients undergoing orthopedic surgery, particularly when locoregional anesthesia is not feasible. The study compares methadone to sufentanil, focusing on pain control during the first 24 hours after surgery. It aims to determine if methadone's long half-life can provide superior pain relief without increasing adverse effects. The trial includes patients aged 18 to 80 undergoing elective hip or knee arthroplasty.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 80 years old
* ASA 1-3 status
* Elective partial or total hip and knee arthroplasty

Exclusion Criteria:

* Patient refusal
* Preoperative renal failure (serum creatinine \> 2 mg/dL or 1.5-fold
* Increase in basal plasma creatinine or GFR \< 90 ml/min/1.73m2)
* Significant hepatic dysfunction (PT \<50% or increase in 3 times basal transaminases)
* Known heart failure
* Preoperative hemodynamic instability (preoperative use of inotropes or vasopressors)
* Known methadone or sufentanil allergy
* Preoperative opioid use or history of opioid abuse
* Pregnancy and breastfeeding.

Where it's running

• CHU Brugmann
  Brussels, Belgium Recruiting

Study contacts

• Study coordinator: Riccardo Mora, MD
• Email: riccardo.mora@chu-brugmann.be
• Phone: 00393292199132

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.