Using melatonin to manage pain after kidney surgery
Effect of Melatonin on Postoperative Pain After Simple Nephrectomy: A Randomized Double-Blinded Controlled Study
This study is testing if melatonin can help reduce pain after kidney surgery for adults aged 18 to 65.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 2 sites (Cairo and 1 other locations) |
| Trial ID | NCT06872944 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of melatonin in reducing postoperative pain in patients undergoing simple nephrectomy. It involves 40 participants aged 18 to 65, who will be divided into two groups to compare pain scores, morphine consumption, and other outcomes post-surgery. The study will assess various factors including hemodynamics, anxiety levels, patient satisfaction, and any adverse events. All patients will receive a preoperative evaluation and be instructed on pain assessment using a visual analog scale.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 with ASA physical status I or II who are scheduled for simple nephrectomy.
Not a fit: Patients with a history of allergic reactions to melatonin, those with certain medical conditions, or those on specific medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management and reduced reliance on opioids after kidney surgery.
How similar studies have performed: While the use of melatonin for pain management is being explored, this specific application in postoperative nephrectomy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years. * Both sexes. * (ASA) physical status I, II. * Patients undergoing simple nephrectomy. Exclusion Criteria: * Patient refusal. * Patients with a history of allergic reactions to melatonin. * Patients receiving drugs with known analgesic and sedative properties. * Body Mass Index (BMI) over 30 kg/m2. * Drug or alcohol abuse. * History of cardiovascular disease. * Renal Failure. * Mental impairment. * Renal impairment.
Where this trial is running
Cairo and 1 other locations
- Faculty of Medicine-Cairo Univeristy — Cairo, Egypt (Recruiting)
- Faculty of Medicine- Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: karim hussein, MD
- Email: karim.ghaleb87@gmail.com
- Phone: 00201007451161
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.