Using medical grade honey to treat cervical pre-cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the effects of medical grade honey on women diagnosed with cervical intraepithelial neoplasia II (CIN II) and high-risk human papillomavirus (hr-HPV). It includes 60 patients who will receive honey treatment as part of an expectant management approach, while a control group will not use honey. Follow-up assessments will occur at six months, including swabs for vaginal microbiota analysis and immunohistochemical evaluations of immune responses. The study aims to determine if honey can enhance the clearance of hr-HPV and normalize CIN II lesions compared to standard management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women 18-40 years
* Primary CIN II confirmed histologically in the biopsy on colposcopic examination
* Sufficient mastery of the Dutch language

Exclusion Criteria:

* Simultaneous abnormality in columnar epithelial cells (AIS).
* Hr-HPV negative cytology
* Immunosuppressant use/Autoimmune disease (HIV, CVID)
* History of cervical carcinoma or previous treatment for CIN (LLETZ or imiquimod)
* Pregnancy or the intention to become pregnant during the study period
* Legal incompetence
* Known allergies to honey

Where it's running

• Zuyderland MC
  Heerlen, Limburg, Netherlands Recruiting
• Maastricht University Medical Centre+
  Maastricht, Limburg, Netherlands Not yet recruiting

Study contacts

• Study coordinator: Jordy Mongula, dr.
• Email: j.mongula@zuyderland.nl
• Phone: +31621872080

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.