Using manual acupuncture to lower uric acid levels in patients without symptoms
Official title: Efficacy and Safety Study of Manual Acupuncture (MA) on Serum Uric Acid (SUA) Outcomes in Patients With Asymptomatic Hyperuricemia (HUA): a Multi-center, Randomized, Sham-controlled Trial
Run by Tongji Hospital · NCT06824376 · Data updated 2026-11-12
This study is testing if manual acupuncture can help lower uric acid levels in people who have high uric acid but no symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 260 (estimated) |
| Sponsor | Tongji Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Wuhan, Hubei) |
| Status | Recruiting |
| Started | March 25, 2025 |
| Main results expected | October 2026 |
| Study ends | December 2026 |
| Registry record updated | March 30, 2025 |
| Trial ID | NCT06824376 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults with asymptomatic hyperuricemia and elevated serum uric acid levels who have not received uric acid-lowering treatments recently.
✕Probably not a fit
Patients with a history of gouty arthritis, poorly controlled hypertension, diabetes, or severe liver and kidney damage may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter, randomized, single-blind, sham-controlled trial aims to evaluate the effectiveness of manual acupuncture in reducing serum uric acid levels in patients diagnosed with asymptomatic hyperuricemia. A total of 260 eligible participants will be randomly assigned to receive either manual acupuncture or sham acupuncture. The study will assess the impact of these interventions on uric acid levels after participants have followed a low-purine diet for one month. The trial seeks to provide insights into alternative treatment options for managing hyperuricemia.
Why it matters
Potential benefit: If successful, this study could offer a non-pharmacological approach to managing serum uric acid levels, potentially reducing the risk of developing gout.
How similar studies have gone: While acupuncture has been explored in various contexts, this specific approach to treating asymptomatic hyperuricemia is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * With serum uric acid (SUA) level \>7 mg/dL after 1 month of a low-purine diet. * No history of gouty arthritis. * Has not received uric acid-lowering drug treatment or stopped uric acid- lowering drug treatment ≥ 12 weeks. * 18.5kg/m2 ≤ body mass index (BMI) ≤ 30.0 kg/m2. * Can write informed consent. Exclusion Criteria: * Patients with poorly controlled hypertension: systolic blood pressure (SBP) ≥ 160mmHg, diastolic blood pressure (DBP) ≥ 100 mmHg. * Patients with poorly controlled diabetes (hemoglobin A1c ≥ 8.4%). * Patients with severe liver and kidney damage: chronic kidney disease (CKD) ≥ stage 2 or a serum creatinine, urea, alanine, or aspartate aminotransferase level more than twice of the upper limit. * Patients with blood system diseases, such as acute and chronic leukemia, polycythemia, multiple myeloma, hemolytic anemia, lymphoma, or undergoing chemotherapy for multiple solid tumors. * Patients with stroke, coronary heart disease, or severe neuropsychological diseases. * Patients who are pregnant. * Illiterate or unwilling to accept acupuncture treatment.
Where it's running
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Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China Recruiting
Study contacts
- Principal investigator: Shenghao Tu, Ph.D — Tongji Hospital
- Study coordinator: Shenghao Tu, PhD
- Email: shtu@tjh.tjmu.edu.cn
- Phone: 86-13971535353
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.