Clinical trial Recruiting at 1 site Interventional Ages 20 to 70

Using magnetic stimulation to treat somatic symptom disorder

Official title: Use Repetitive Transcranial Magnetic Stimulation to Treat Somatic Symptom Disorder: A Randomized Double-blind Sham-controlled Crossover Study

Run by National Taiwan University Hospital · NCT05161819 · Data updated 2026-11-12

This study is testing if a type of magnetic stimulation can help people with somatic symptom disorder feel less distress and anxiety about their health.

Quick facts

Study typeInterventional
Ages20 Years to 70 Years
SexAll
Enrollment30 (estimated)
SponsorNational Taiwan University Hospital
Academic / other
Locations1 site (Douliu, Yunlin)
StatusRecruiting
StartedAugust 29, 2022
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedMarch 18, 2026
Trial IDNCT05161819 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 20-70 diagnosed with somatic symptom disorder.

Probably not a fit

Patients with psychotic symptoms, cognitive impairment, or those with certain medical conditions or medications may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of repetitive transcranial magnetic stimulation (rTMS) on the left dorsolateral prefrontal cortex in treating somatic symptom disorder (SSD). It employs a randomized double-blind sham-controlled crossover design, where participants will receive either active rTMS or a sham treatment. The primary outcomes measured will be somatic distress and health anxiety, which are key symptoms of SSD. The study aims to explore whether rTMS can provide relief for patients suffering from this condition, which often overlaps with other functional disorders.

Why it matters

Potential benefit: If successful, this treatment could significantly reduce somatic distress and health anxiety in patients with somatic symptom disorder.

How similar studies have gone: Previous studies have shown that rTMS can be effective for conditions like depression and fibromyalgia, suggesting potential success for this approach in treating somatic symptom disorder.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient with somatic symptom disorder (confirmed by psychiatrists)
* Age 20-70

Exclusion Criteria:

* Having psychotic symptoms or cognitive impairment
* Having potentially lethal illness
* Using cardiac pacemakers or defibrillators
* Currently pregnant or having plans to become pregnant within the next three months
* Received rTMS treatment within three months
* Cannot read the questionnaires by oneself
* Having to take the following medications persistently: bupropion \>300 mg/day、TCA、clozapine、chlorpromazine、foscarnet、ganciclovir、ritonavir、theophylline

Where it's running

  • National Taiwan University Hospital Yunlin Branch
    Douliu, Yunlin, Taiwan
    Recruiting

Study contacts

  • Principal investigator: Wei-Lieh Huang, MD, PhD — National Taiwan University Hospital
  • Study coordinator: Wei-Lieh Huang, MD, PhD
  • Email: weiliehhuang@gmail.com
  • Phone: 886-5-5323911

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.