Using magnetic stimulation to improve muscle function in spinal muscular atrophy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and tolerability of low motoneuron stimulation using transcranial magnetic stimulation (TMS) in patients with spinal muscular atrophy (SMA). The approach aims to mimic the effects of physical exercise, which can be challenging for SMA patients due to physical and psychological limitations. By applying high-frequency repetitive TMS, the study seeks to engage weak muscle groups and provide therapeutic benefits without requiring active participation from the patients. The study includes specific eligibility criteria to ensure that participants can safely engage with the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subject has a diagnosis of 5q-autosomal recessive SMA confirmed by DNA test.
* Informed consent.
* A minimum score of 1 for Entry Item "A" of the Revised Upper Limb Module (RULM) scale for SMA: "Can use hands to hold pencil or pick up a coin/token or drive a powered chair, use phone key pad"

Exclusion Criteria:

* Subject has severe joint contractures that would affect ability to perform study measures, determined by the study physician.
* Subject has a deconditioned respiratory system, per the discretion of the physician investigator.
* Subject has behavioral or cognitive problems that preclude participation in the study, in the opinion of the investigator.

Where it's running

• P.V. Voloshyn Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine
  Kharkiv, Kharkiv Oblast, Ukraine Recruiting

Study contacts

• Principal investigator: Olena V Pisotska, MD, PhD — P.V. Voloshyn Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine
• Study coordinator: Vitaliy M Matyushenko
• Email: csma.ua@gmail.com
• Phone: 380503640673

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Biomarker search in SMA using advanced multi-omics

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• Effects of Different Stiffness Settings During Robotic Isokinetic Training in Children With SMA

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• Wearable monitoring of motor development in babies and young children with spinal muscular atrophy detected at birth

  This project will try wearing small motion sensors at home to see if they can track how babies and young children diagnosed with spinal muscular atrophy at birth move and develop, compared with healthy children.

  Recruiting University of Oxford · Oxford · NCT07543003

• HABIT-ILE plus Functional Strength Training for Children with SMA

  This study will try an intensive HABIT-ILE program combined with functional strength training for children aged 5–17 with SMA who are on stable disease-modifying therapy to see if it improves motor skills.

  Recruiting Teachers College, Columbia University · New York, New York · NCT07488338

• Long-read genetic analysis for Spinal Muscular Atrophy (LOREASI)

  This project tries a long-read DNA technique on adults with known SMN1 copy-number patterns to find hidden '2+0' carrier genotypes that standard tests miss.

  Recruiting University Hospital, Rouen · Rouen · NCT07332702

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.