Clinical trial Recruiting at 1 site Observational

Using machine learning to predict success in weaning patients off mechanical ventilation

Official title: Prediction of the Spontaneous Breathing Test Success Using Biosignal and Biomarker in Critical Care Unit by a Machine Learning Approach

Run by Centre Hospitalier Universitaire de Nice · NCT05886803 · Data updated 2026-11-12

This study is testing a new way to use machine learning to see if it can help doctors predict which patients in critical care will successfully breathe on their own after being on a ventilator.

Quick facts

Study typeObservational
SexAll
Enrollment500 (estimated)
SponsorCentre Hospitalier Universitaire de Nice
Academic / other
Locations1 site (Nice)
StatusRecruiting
StartedJanuary 1, 2023
Main results expectedDecember 12, 2024
Study endsJune 25, 2027
Registry record updatedJune 29, 2026
Trial IDNCT05886803 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients in critical care units who have undergone a spontaneous breathing test and have corresponding biosignal data available.

Probably not a fit

Patients who have not undergone a spontaneous breathing test or whose biosignal data is not recorded will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a predictive algorithm using machine learning techniques to assess the likelihood of success in spontaneous breathing tests for patients in critical care units. By analyzing biosignals such as cardiac rate and ventilatory parameters, the study seeks to improve decision-making during the weaning process from mechanical ventilation. The goal is to enhance patient outcomes by reducing morbidity and mortality associated with difficult weaning attempts. The study will include patients who have undergone spontaneous breathing tests and have relevant biosignal data recorded in their health reports.

Why it matters

Potential benefit: If successful, this approach could significantly improve the management of patients undergoing mechanical ventilation by accurately predicting weaning success.

How similar studies have gone: While few studies have explored machine learning in this context, the approach of using biosignals for prediction is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Computerized health report (CHR)
* Spontaneous breathing test should have been performed

Exclusion Criteria:

* Spontaneous breathing test has not been performed,
* Biosignal (cardiac, respiratory) are not registered in the CHR
* Patient died before the spontaneous breathing test
* Opposition to the study has been expressed.

Where it's running

  • University Hospital of Nice
    Nice, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.