Using machine learning to predict success in weaning patients off mechanical ventilation
Official title: Prediction of the Spontaneous Breathing Test Success Using Biosignal and Biomarker in Critical Care Unit by a Machine Learning Approach
Run by Centre Hospitalier Universitaire de Nice · NCT05886803 · Data updated 2026-11-12
This study is testing a new way to use machine learning to see if it can help doctors predict which patients in critical care will successfully breathe on their own after being on a ventilator.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Status | Recruiting |
| Started | January 1, 2023 |
| Main results expected | December 12, 2024 |
| Study ends | June 25, 2027 |
| Registry record updated | June 29, 2026 |
| Trial ID | NCT05886803 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients in critical care units who have undergone a spontaneous breathing test and have corresponding biosignal data available.
✕Probably not a fit
Patients who have not undergone a spontaneous breathing test or whose biosignal data is not recorded will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to develop a predictive algorithm using machine learning techniques to assess the likelihood of success in spontaneous breathing tests for patients in critical care units. By analyzing biosignals such as cardiac rate and ventilatory parameters, the study seeks to improve decision-making during the weaning process from mechanical ventilation. The goal is to enhance patient outcomes by reducing morbidity and mortality associated with difficult weaning attempts. The study will include patients who have undergone spontaneous breathing tests and have relevant biosignal data recorded in their health reports.
Why it matters
Potential benefit: If successful, this approach could significantly improve the management of patients undergoing mechanical ventilation by accurately predicting weaning success.
How similar studies have gone: While few studies have explored machine learning in this context, the approach of using biosignals for prediction is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Computerized health report (CHR) * Spontaneous breathing test should have been performed Exclusion Criteria: * Spontaneous breathing test has not been performed, * Biosignal (cardiac, respiratory) are not registered in the CHR * Patient died before the spontaneous breathing test * Opposition to the study has been expressed.
Where it's running
-
University Hospital of Nice
Nice, France Recruiting
Study contacts
- Study coordinator: Romain LOMBARDI
- Email: lombardi.r@chu-nice.fr
- Phone: 0669032616
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Breathlessness during ventilator weaning in obese ICU patients
This project will measure how often and how severe breathlessness is when obese ICU patients try to breathe on their own during ventilator weaning.
-
Capillary vs arterial blood gas analysis in COPD or APE patients with respiratory distress
This study tests whether a capillary blood gas test can replace the arterial test in adults with COPD flare or cardiogenic pulmonary edema who need non-invasive ventilation.
-
BiP inhibitor BPR001-615 in colorectal adenocarcinoma
This study tests whether the BiP inhibitor BPR001-615 can affect cancer cells from colorectal adenocarcinoma, in patients who will have surgical removal of their tumor at Nice University Hospital.
-
Three CT Signs of Nerve-Root Suffering in Low-Back Sciatica: How Often They Occur in Patients Referred for CT-Guided Nerve-Root Infiltration
This study tests whether three specific CT signs align with the nerve root causing symptoms in adults with low-back sciatica who are scheduled for CT-guided nerve-root infiltration.
-
Innate immune cells in abdominal inflammation: observing their behavior in patients undergoing digestive surgery
This study tests how innate immune cells behave during inflammatory episodes by analyzing non-invasively collected abdominal fluid from adults having digestive surgery.
-
Two anesthesia methods to keep the joint clear during shoulder arthroscopy
This trial tests whether inhaled sevoflurane vs. total intravenous anesthesia with propofol affects how well surgeons can see inside the shoulder during rotator cuff repair.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.