Using LungVision navigation to place markers on ground-glass lung nodules before surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses the LungVision augmented fluoroscopy navigation system combined with pre-procedure high-resolution CT and radial endobronchial ultrasound to guide bronchoscopy and place small fiducial markers into partially solid ground-glass pulmonary nodules. Markers are placed bronchoscopically under deep sedation so surgeons can more easily locate the lesion during subsequent minimally invasive surgery. The approach aims to reduce complications associated with percutaneous transthoracic marking, such as pneumothorax, and to enable smaller, tissue-sparing resections. Enrollment is at a single academic center in Bologna, Italy, with eligibility based on lesion size and presence of a bronchus sign on CT.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years;
* Evidence of a partially solid peripheral pulmonary nodule with a solid component ≥ 6 mm or increasing in size, even if smaller, with a bronchus sign or adjacent bronchus on chest CT;
* Obtaining the patient's informed consent.

Exclusion Criteria:

* Pregnancy or suspected pregnancy;
* Contraindication to performing bronchoscopy under deep sedation, based on the anesthesiologist's assessment;
* Patient not eligible for surgery due to high surgical risk, based on the anesthesiologist's assessment.

Where it's running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna
  Bologna, Bologna, Italy Recruiting

Study contacts

• Principal investigator: Piero Candoli, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
• Study coordinator: Piero Candoli, MD
• Email: piero.candoli@aosp.bo.it
• Phone: +39 051 2145251

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.