Using lung ultrasound to predict extubation success in newborns with respiratory distress
The Utility of Lung Ultrasound Scores to Determine Extubation Readiness in Neonates With Respiratory Distress on Mechanical Ventilation
This study is testing if lung ultrasound can help doctors predict if newborns with breathing problems can safely be taken off a breathing machine.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | N/A to 6 Months |
| Sex | All |
| Sponsor | University of Wisconsin, Madison Academic / other |
| Locations | 2 sites (Minneapolis, Minnesota and 1 other locations) |
| Trial ID | NCT06140615 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of lung ultrasound in predicting whether neonates with respiratory distress can successfully be extubated. Participants will undergo lung ultrasound examinations both before and after the extubation process. The study is being conducted at UnityPoint Health Meriter Hospital and the University of Minnesota, focusing on infants admitted to the Neonatal Intensive Care Unit (NICU) who require intubation. The goal is to improve clinical decision-making regarding extubation in this vulnerable population.
Who should consider this trial
Good fit: Ideal candidates are infants born at the participating hospitals who are admitted to the NICU with respiratory distress requiring intubation.
Not a fit: Patients with known major congenital diseases or whose parents are under 18 years old may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the ability to predict extubation outcomes, potentially reducing complications and improving recovery times for newborns.
How similar studies have performed: While the specific approach of using lung ultrasound for this purpose may be novel, similar studies in other contexts have shown promise in using ultrasound for respiratory assessments.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Infants born at UnityPoint Health Meriter Hospital and University of Minnesota admitted to the Neonatal Intensive Care Unit (NICU) with respiratory distress requiring intubation * Meeting the extubation readiness criteria per the attending neonatologist Exclusion Criteria: * Known major congenital disease (chromosomal abnormality, heart disease, respiratory malformation) * Neonates with parents that are less than 18 years old
Where this trial is running
Minneapolis, Minnesota and 1 other locations
- University of Minnesota — Minneapolis, Minnesota, United States (Recruiting)
- Unity-Point Health Meriter — Madison, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Adam S Bauer, MD — Meriter Foundation
- Study coordinator: Adam S Bauer, MD
- Email: adam.bauer@wisc.edu
- Phone: 608-417-6411
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.