Using lung ultrasound to optimize fluid management in high-risk surgical patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of lung ultrasound to guide hemodynamic optimization in patients undergoing non-cardiac surgery. It aims to assess whether measuring stroke volume through lung ultrasound can improve patient outcomes by preventing vascular overload and reducing postoperative complications. The study will involve administering noradrenaline and monitoring vascular filling based on ultrasound findings. The goal is to establish a more effective method for managing fluid therapy in high-risk surgical patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age\> 18 years old
* Abdominal, orthopaedic or vascular surgery with general anaesthesia
* Patient of legal age ≥ 18 years.
* ASA score ≥ II
* Estimated duration of surgery \> 2 hours
* At least two of the following comorbidities (age \> 50 years, hypertension, heart disease, electrocardiogram (ECG) abnormality, acute pulmonary oedema, smoking, stroke, peripheral arterial disease, non-insulin dependent or insulin dependent diabetes, ascites, chronic renal failure)
* Signed consent.
* Affiliation to a social security scheme.

Exclusion Criteria:

* Severe untreated or unbalanced hypertension on treatment.
* Preoperative renal failure on dialysis.
* Acute heart failure.
* Acute coronary insufficiency.
* Vascular surgery with renal plasty.
* Cardiac surgery.
* Preoperative shock.
* Refusal of patient participation.
* Pregnant, parturient or breastfeeding woman.
* Patient under guardianship or private law.
* Acute respiratory distress syndrome according to the Berlin definition
* respiratory distress not fully explained by cardiac failure or increased blood volume,
* PaO2/FiO2 ratio ≤ 300 mm Hg on mechanical ventilation (invasive or non-invasive)
* Chronic respiratory failure with home oxygen therapy.
* Chronic interstitial lung disease
* Presence of an acoustic barrier (pneumothorax, subcutaneous emphysema, pleural calcifications, chest bandage, gunshot shrapnel...)
* Participation in other interventional drug research.
* Surgical fields covering the sites of investigation in lung ultrasound.

Where it's running

• CHU Amiens
  Amiens, France Recruiting

Study contacts

• Study coordinator: Stéphane BAR, DR
• Email: bar.stephane@chu-amiens.fr
• Phone: 03 22 08 79 06

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Continuous wearable vital-sign monitoring versus routine spot-checks after non-cardiac surgery

  This trial will test whether continuous wearable vital-sign monitoring can reduce the time abnormal signs go unnoticed in adults recovering on regular wards after major non-cardiac surgery.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT07385092

• Heart injury after lumbar spine surgery

  This study will see how often heart injury (MINS) happens and which factors raise the risk in adults having elective lumbar stabilization surgery.

  Recruiting Ankara City Hospital Bilkent · Ankara · NCT07081009

• Can newly trained clinicians use bedside lung ultrasound to detect a collapsed lung after heart surgery?

  This study will test whether medical trainees can use a bedside lung ultrasound to find a collapsed lung in adults after heart surgery.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07018856

• Lung ultrasound to guide antibiotic decisions in children with pneumonia

  This will see if using lung ultrasound for children aged 3–10 with suspected pneumonia leads to fewer antibiotic prescriptions than usual care.

  Recruiting at 7 sites Meyer Children's Hospital IRCCS · San Diego, California and 17 other locations · NCT06921993

• Noradrenaline versus usual blood pressure care during non-cardiac surgery

  This test tries a continuous noradrenaline infusion during and for four hours after non-cardiac surgery to see if it reduces episodes of low blood pressure in adults aged 45 and older compared with usual blood pressure care.

  Recruiting at 4 sites Phase 3 Jagiellonian University · Katowice and 4 other locations · NCT06885268

• Low-dose Esketamine for preventing delirium in elderly patients undergoing surgery

  This study is testing if low-dose Esketamine can help prevent confusion after surgery in older adults aged 65 to 90.

  Recruiting at 3 sites Nanfang Hospital, Southern Medical University · Fuzhou, Fujian and 5 other locations · NCT06817239

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.