Using lung ultrasound to optimize breathing support during prostate or bladder surgery
Intraoperative Bedside Lung-ultrasound Use to Optimize Positive End-expiratory Pressure for Elective Robotic-assisted Radical Prostatectomy or Cystectomy Patients: a Randomized Controlled Trial
This study is testing if using lung ultrasound can help doctors adjust breathing support during prostate or bladder surgery to keep patients safe and comfortable.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 88 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06307704 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of using lung ultrasound to guide the optimization of Positive End Expiratory Pressure (PEEP) in patients undergoing robotic-assisted radical prostatectomy or cystectomy. The approach aims to prevent lung complications such as atelectasis while ensuring adequate oxygenation and compliance during surgery. By employing a stepwise PEEP titration based on lung ultrasound findings, the study seeks to improve patient outcomes without the need for complex devices. The intervention is designed to be quick, cost-effective, and easily applicable in the operating room setting.
Who should consider this trial
Good fit: Ideal candidates for this study are patients classified as ASA I, II, or III with normal respiratory functions or mild lung disease.
Not a fit: Patients with a BMI over 40, moderate to severe obstructive or restrictive pulmonary disease, or severe pulmonary hypertension are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative lung complications and improve recovery for patients undergoing these surgeries.
How similar studies have performed: Previous studies have shown that ultrasound-guided PEEP titration can be effective in other surgical contexts, suggesting potential success for this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I, II \& III. * Normal respiratory functions or mild lung disease. Exclusion Criteria: * BMI more than 40. * Moderate to severe obstructive pulmonary disease (FEV1 \< 80% of predicted). * Moderate to severe restrictive pulmonary disease (TLC \< 70% of predicted). * Severe pulmonary hypertension (mean PAP\>55). * Previous lung surgery. * Decompensated cardiac disease (NYHA 3 or 4). * Patients who received invasive mechanical ventilation within the last 30 days before surgery.
Where this trial is running
Cairo
- Cairo University Hospitals — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Nazmy S Mikhael, MD — Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University
- Study coordinator: Mustafa E Mohamed, MD
- Email: mustafaemam931@gmail.com
- Phone: 01140806330
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.