Using lung ultrasound patterns to predict weaning outcomes in ventilated patients
The Impact of Lung Ultrasound Morphology Patterns on Treatment Response and Weaning Outcomes in High-Risk Mechanically Ventilated Patients
This study is testing if using lung ultrasound patterns can help doctors better decide when to take patients off ventilators in older patients or those with chronic heart or lung diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Shanghai Zhongshan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06521515 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how lung ultrasound morphology patterns affect treatment responses and weaning outcomes in high-risk patients on mechanical ventilation. Conducted in an ICU, it includes patients over 65 years or with chronic heart or lung diseases who have been ventilated for more than 24 hours. Participants will undergo daily lung ultrasound examinations to categorize their lung aeration patterns, which will guide targeted clinical interventions. The study aims to improve patient outcomes by tailoring treatment based on ultrasound findings.
Who should consider this trial
Good fit: Ideal candidates are patients over 65 years old or those with chronic heart or lung diseases who have been on mechanical ventilation for over 24 hours.
Not a fit: Patients under 18 years, those with low risk of extubation failure, or those with do-not-reintubate orders will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance weaning success rates and reduce reintubation risks in high-risk patients.
How similar studies have performed: Other studies have shown promising results using lung ultrasound for similar purposes, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria:(1) age ≥18 years, (2) on mechanical ventilation \>24 hours before the first spontaneous breathing trial, (3) high risk for reintubation due to age (\>65 years) or chronic heart or lung disease, and (4) complete ultrasound data and initial LUS \>13. Exclusion criteria:(1) age under 18 years, pregnancy, mechanical ventilation duration less than 24 hours, or diaphragmatic dysfunction; (2) low risk of extubation failure; (3) peripheral neuromuscular disorders; or (4) do-not-reintubate order at the first spontaneous breathing trial.
Where this trial is running
Shanghai, Shanghai Municipality
- Hongyu He — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Hongyu He
- Email: he.hongyu@zs-hospital.sh.cn
- Phone: 021-64041990
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.