Using low dose ketamine or fentanyl with propofol-dexmedetomidine for anesthesia in brain surgery
Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia for Patients Undergoing Craniotomy
This study is testing whether adding low doses of ketamine or fentanyl to a common anesthesia mix can help people having brain surgery feel better during and after the procedure.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya) |
| Trial ID | NCT06031883 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of adding low doses of ketamine or fentanyl to a combination of propofol and dexmedetomidine for total intravenous anesthesia in patients undergoing elective craniotomy for supratentorial brain tumors. The research focuses on various outcomes including brain relaxation scores, hemodynamic stability, surgeon satisfaction, and the total requirement of intraoperative propofol and postoperative analgesia. By comparing these combinations, the study aims to determine the optimal anesthesia approach for this specific surgical procedure.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-70 with a GCS of 14-15, ASA I-III, and a BMI of less than 35 scheduled for elective craniotomy.
Not a fit: Patients with severe comorbidities, uncontrolled hypertension, or allergies to the study drugs may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance anesthesia management, improve surgical conditions, and reduce postoperative pain for patients undergoing craniotomy.
How similar studies have performed: Other studies have shown promising results with similar anesthesia approaches, indicating potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - Patients aged 18-70 years old ASA I - III with GCS 14-15 and BMI\<35 scheduled for elective craniotomy for resection of supratentorial masses Exclusion Criteria: * Patients will be excluded if they will refuse to give a written consent. Also patients with GCS \< 14 or having endocrine or blood diseases or sever cardiac disease or sever liver disease or renal failure and patients with uncontrolled hypertension or uncontrolled diabetes mellitus and patients have allergy to any of the study drugs.
Where this trial is running
Minya
- Eron — Minya, Egypt (Recruiting)
Study contacts
- Study coordinator: Eron Ashraf Faried
- Email: roneashraf20@gmail.com
- Phone: 01066197115
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.