Using low dose injectable progesterone to trigger ovulation
Official title: Role of Low Dose Injectable Progesterone in Triggering Ovulation: A Randomized Controlled Trial
Run by The General Authority for Teaching Hospitals and Institutes · NCT06928844 · Data updated 2026-11-12
This study is testing whether a low dose of injectable progesterone can help women aged 20 to 35 with unexplained infertility to ovulate better than a placebo.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 35 Years |
| Sex | Women only |
| Enrollment | 120 (estimated) |
| Sponsor | The General Authority for Teaching Hospitals and Institutes Research network |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | April 15, 2025 |
| Main results expected | August 1, 2025 |
| Study ends | August 1, 2025 |
| Registry record updated | April 16, 2025 |
| Trial ID | NCT06928844 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are infertile women aged 20 to 35 with normal basal FSH levels.
✕Probably not a fit
Patients with poor ovarian reserve, immunological diseases, endometriosis, uterine abnormalities, high BMI, or abnormal endometrial thickness may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of low dose injectable progesterone in triggering ovulation in women experiencing infertility. It focuses on women aged 20 to 35 with unexplained infertility and normal basal follicle-stimulating hormone levels. The study compares the outcomes of progesterone treatment against a placebo to determine its impact on ovulation induction. The research aims to provide insights into alternative methods for enhancing fertility in women undergoing assisted reproductive technologies.
Why it matters
Potential benefit: If successful, this approach could offer a new, effective treatment option for women struggling with unexplained infertility.
How similar studies have gone: While the use of progesterone in fertility treatments is established, this specific approach of low dose injectable progesterone for triggering ovulation is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 20 to 35 years. * Infertile women. * Basal follicle-stimulating hormone (FSH) level \<10 mIU/ml. Exclusion Criteria: * Poor ovarian reserve. * Immunological disease. * Endometriosis. * Uterine abnormality. * Body mass index (BMI) \>30 kg/m2. * Endometrial thickness \<8 or \>12 mm on the day of triggering.
Where it's running
-
Teaching Hospitals and Institutes
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Abeer A El Shabasi, MD
- Email: abear.elshabacy@gmail.com
- Phone: 00201223331182
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.