Using liraglutide to prevent delirium in elderly diabetic patients after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of liraglutide, a medication commonly used for Type 2 diabetes, in preventing postoperative delirium in elderly patients undergoing cardiac surgery. Delirium is a significant complication that can lead to increased mortality and longer hospital stays. The trial will compare the effects of liraglutide injections against placebo injections in this patient population. By targeting neuroinflammation, the study aims to reduce the incidence of delirium and improve postoperative outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 60 years
2. Type 2 diabetes
3. Patients undergoing elective cardiac surgery

Exclusion Criteria:

1. History of neurological or psychiatric disorders, such as schizophrenia, epilepsy, Parkinson's disease, severe dementia, etc
2. Patients with communication difficulties, such as severe visual, auditory, or speech impairments
3. History of central nervous system damage or surgery
4. Cardiac function NYHA Class IV
5. Severe liver dysfunction (Child-Pugh Class C)
6. Severe renal failure requiring renal replacement therapy
7. History of pancreatitis
8. Type 1 diabetes
9. Patients whose blood sugar is difficult to control within 4-8 mmol/L during the screening period
10. Patients with medullary thyroid carcinoma or a family history of it
11. Pregnant or breastfeeding women
12. Intolerance or allergy to liraglutide
13. Previous use of GLP-1A and SGLT2i
14. Patients who refuse to sign the informed consent

Where it's running

• Wenxue liu
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Dongjin Wang, PhD，MD — Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
• Study coordinator: Wenxue Liu, PhD，MD
• Email: diligent_hi@163.com
• Phone: 15751866806

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.