Using liquid biopsies to detect mutations in brain arteriovenous malformations
Liquid Biopsies for the Detection of Somatic Mutations in Brain Arteriovenous Malformations
This study is testing if a simple blood test can help find genetic changes in people with brain arteriovenous malformations to better understand their condition and improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT06494358 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the use of liquid biopsies to identify somatic mutations in patients with brain arteriovenous malformations (bAVMs). It aims to explore the genetic underpinnings of bAVMs, which have traditionally been considered non-genetic, by analyzing circulating DNA. The study will involve patients treated at Pitié-Salpêtrière Hospital who are undergoing embolization followed by surgery. By utilizing next-generation sequencing, the research seeks to provide a non-invasive method for studying these mutations and potentially guiding treatment strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are being treated for bAVMs at Pitié-Salpêtrière Hospital and are indicated for embolization followed by surgery.
Not a fit: Patients with extra-cerebral arteriovenous malformations, those under legal protection, pregnant individuals, or those not eligible for combined treatment will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized treatment options for patients with bAVMs, improving outcomes and reducing risks associated with these malformations.
How similar studies have performed: While the use of liquid biopsies is a relatively novel approach in this context, there is emerging evidence supporting its effectiveness in other vascular conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
"\_Age ≥ 18 years * Treated for bAVM at Pitié-Salpêtrière Hospital * Indication for treatment by embolization followed by surgery decided in a multidisciplinary consultation meeting (RCP) at Pitié-Salpêtrière Hospital * Treatment by embolization possibly followed by surgery within 24-48 hours if the embolization is incomplete * Informed about the study and not objecting to participation" Exclusion criteria : * Extra-cerebral arteriovenous malformations * Under legal protection (guardianship/curators, etc.) * Pregnancy * Not eligible for combined treatment (embolization followed by surgery)
Where this trial is running
Paris
- Unité de neuroradiologie interventionnelle, hôpital Pitié-Salpêtrière — Paris, France (Recruiting)
Study contacts
- Study coordinator: Frederic Clarençon, MD,PhD
- Email: frederic.clarencon@aphp.fr
- Phone: 0033 1 42 16 35 99
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.