Using liquid biopsies to detect mutations in brain arteriovenous malformations
Official title: Liquid Biopsies for the Detection of Somatic Mutations in Brain Arteriovenous Malformations
Run by Assistance Publique - Hôpitaux de Paris · NCT06494358 · Data updated 2026-11-12
This study is testing if a simple blood test can help find genetic changes in people with brain arteriovenous malformations to better understand their condition and improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | December 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | August 31, 2026 |
| Trial ID | NCT06494358 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who are being treated for bAVMs at Pitié-Salpêtrière Hospital and are indicated for embolization followed by surgery.
✕Probably not a fit
Patients with extra-cerebral arteriovenous malformations, those under legal protection, pregnant individuals, or those not eligible for combined treatment will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on the use of liquid biopsies to identify somatic mutations in patients with brain arteriovenous malformations (bAVMs). It aims to explore the genetic underpinnings of bAVMs, which have traditionally been considered non-genetic, by analyzing circulating DNA. The study will involve patients treated at Pitié-Salpêtrière Hospital who are undergoing embolization followed by surgery. By utilizing next-generation sequencing, the research seeks to provide a non-invasive method for studying these mutations and potentially guiding treatment strategies.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized treatment options for patients with bAVMs, improving outcomes and reducing risks associated with these malformations.
How similar studies have gone: While the use of liquid biopsies is a relatively novel approach in this context, there is emerging evidence supporting its effectiveness in other vascular conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
"\_Age ≥ 18 years * Treated for bAVM at Pitié-Salpêtrière Hospital * Indication for treatment by embolization followed by surgery decided in a multidisciplinary consultation meeting (RCP) at Pitié-Salpêtrière Hospital * Treatment by embolization possibly followed by surgery within 24-48 hours if the embolization is incomplete * Informed about the study and not objecting to participation" Exclusion criteria : * Extra-cerebral arteriovenous malformations * Under legal protection (guardianship/curators, etc.) * Pregnancy * Not eligible for combined treatment (embolization followed by surgery)
Where it's running
-
Unité de neuroradiologie interventionnelle, hôpital Pitié-Salpêtrière
Paris, France Recruiting
Study contacts
- Study coordinator: Frederic Clarençon, MD,PhD
- Email: frederic.clarencon@aphp.fr
- Phone: 0033 1 42 16 35 99
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.