Using light therapy to treat pain in Parkinson's disease patients
Transcranial Photobiomodulation as a Therapy for Patients With Parkinson's Disease: Relationship Between Pain and Brain Functional Connectivity
This study is testing if light therapy can help reduce pain in people with Parkinson's disease who have more pain when their medication isn't working.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 82 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | University of Sao Paulo Academic / other |
| Locations | 2 sites (São Paulo and 1 other locations) |
| Trial ID | NCT05959772 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of transcranial photobiomodulation on patients with Parkinson's disease who experience increased pain when off levodopa. It aims to assess pain intensity and cognitive motor behavior before and after treatment using various scales and tests, including the Visual Analog Scale and the Timed Up Go test. Additionally, the study will analyze brain connectivity related to pain using Functional Magnetic Resonance Imaging (fMRI). The goal is to improve pain management in Parkinson's patients through this innovative therapy.
Who should consider this trial
Good fit: Ideal candidates are patients with Parkinson's disease experiencing pain who can walk independently and understand simple commands.
Not a fit: Patients who are wheelchair users, have severe postural instability, or severe cognitive impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this therapy could significantly reduce pain and improve quality of life for patients with Parkinson's disease.
How similar studies have performed: Other studies have shown promise in using photobiomodulation for pain management, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with Hoehn \& Yahr 3 * Pain from Parkinson's disease * Walk independently * Ability to understand simple command Exclusion Criteria: * Wheelchair users * Severe postural instability * Severe cognitive impairment * Contraindications for MRI, such as dyskinesia or deep brain stimulation
Where this trial is running
São Paulo and 1 other locations
- Mara Evany de Oliveira Silva — São Paulo, Brazil (Recruiting)
- University of São Paulo — São Paulo, Brazil (Recruiting)
Study contacts
- Study coordinator: Mara 55 Evany de Oliveira Silva, Doctor
- Email: maraevany@hotmail.com
- Phone: +55 11 3091-8452
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.