Using light therapy to treat hand-foot syndrome in cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of photobiomodulation therapy (PBMT) in managing hand-foot syndrome (HFS) and hand-foot skin reaction (HFSR) in cancer patients undergoing chemotherapy or targeted therapies. PBMT is a non-invasive treatment that uses specific wavelengths of light to promote healing and reduce pain and inflammation. The study aims to assess the reduction in severity of HFS and HFSR, improve quality of life, and evaluate patient satisfaction and safety over a period of time. Participants will receive PBMT and be monitored for symptom relief and overall well-being.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with cancer of different aetiologies
* Undergoing chemotherapy or targeted therapy (TKIs)
* Diagnosed with HFS-HFSR grade 1, 2 or 3 (National Cancer Institute - Common Terminology Criteria for Adverse Events, NCI-CTCAE v5)
* Age ≥ 18 years
* Able to comply to the study protocol
* Able to sign written informed consent

Exclusion Criteria:

* Pre-existing skin rash, ulceration or open wound in the treatment area (hand, foot)
* Known allergy to polyurethane
* Substance abuse patients or patients with medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results as judged by the investigator
* Any condition that is unstable or could affect the safety of the patient and their compliance in the study as judged by the investigator

Where it's running

• Jessa Ziekenhuis VZW
  Hasselt, Limburg, Belgium Recruiting
• Hasselt University
  Hasselt, Limburg, Belgium Not yet recruiting

Study contacts

• Principal investigator: Jeroen Mebis, MD, PhD — Head of Medical Oncology Department
• Study coordinator: Jeroen Mebis, MD, PhD
• Email: Jeroen.mebis@jessazh.be
• Phone: +32 11 33 72 21

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using electroacupuncture and acupressure to prevent hand-foot syndrome in breast cancer patients on capecitabine

  This study is testing if combining electroacupuncture with self-acupressure can help prevent hand-foot syndrome in breast cancer patients taking capecitabine.

  Recruiting Affiliated Hospital of Qinghai University · Xining, Qinghai · NCT06602167

• Pre-emptive topical indomethacin to prevent sorafenib-related hand-foot syndrome in advanced liver cancer

  This trial will test whether applying 1% indomethacin gel to both hands twice daily can reduce hand-foot syndrome in adults with advanced hepatocellular carcinoma starting sorafenib.

  Recruiting Phase 2 National Taiwan University Hospital · Taipei · NCT07560566

• Using AI to train doctors in pediatric care

  This study is testing whether using virtual patients powered by AI can help train doctors in China to better care for children with common health issues.

  Recruiting at 3 sites Southern Medical University, China · Guiyang, Guizhou and 2 other locations · NCT06699433

• Monitoring hand, foot and mouth disease in children

  This study is trying to find out which types of viruses cause hand, foot, and mouth disease in kids by collecting samples from children with symptoms to help track outbreaks.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06263439

• Evaluating a new vaccine for Hand, Foot, and Mouth Disease in young children

  This study is testing a new vaccine to see if it can help protect young children from Hand, Foot, and Mouth Disease.

  Recruiting at 4 sites Phase 3 Sinovac Biotech Co., Ltd · Hefei, Anhui and 3 other locations · NCT06734832

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.