Using leucine to improve muscle growth in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how leucine supplementation can enhance muscle protein synthesis in older adults aged 65-75 who do not regularly engage in resistance exercise. It aims to determine the optimal timing for leucine intake, either with meals or between meals, to maximize muscle mass gains following exercise. The research addresses the challenge of sarcopenia, a condition characterized by muscle loss and weakness in aging populations, by exploring a nutritional strategy to improve muscle response to exercise.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male, 65-75 years of age
* BMI 18-28 kg/m2
* Non smoker
* Not performing regular resistance type exercise
* Participant is willing and able to give informed consent for participation in the study

Exclusion Criteria:

* A BMI \<18 or \>28 kg·m-2
* Active cardiovascular disease: uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event
* Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)
* Respiratory disease including pulmonary hypertension or chronic obstructive pulmonary disease (COPD)
* Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), inborn/ congenital errors of metabolism (e.g. phenylketonuria (PKU), galactosaemia)
* Active inflammatory bowel disease
* Acute infection
* Acute or chronic renal disease
* Malignancy (or history of malignancy with 5 y)
* Recent steroid treatment (within 6 mo), or hormone replacement therapy
* Coagulopathy
* Musculoskeletal or neurological disorders
* Known allergies to any of the product ingredients
* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance

Where it's running

• University of Nottingham
  Nottingham, Nottinghamshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Matthew Brook, PhD — University of Nottingham
• Study coordinator: Joanne Mallinson, PhD
• Email: joanne.mallinson@nottingham.ac.uk
• Phone: 01158230127

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.