Using Letrozole or Mifepristone for Medical Termination of Pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of letrozole as a pre-treatment for medical termination of pregnancy (mTOP) compared to the standard mifepristone regimen. The study aims to determine if letrozole can achieve similar or improved complete abortion rates while being a more cost-effective and accessible alternative. Participants will receive either letrozole or mifepristone before the administration of misoprostol, with the goal of enhancing the success rates of abortion in the first trimester. The trial will include women aged 21 and above who are eligible for legal abortion and have a singleton pregnancy of up to 10 weeks gestation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 21 years and above
* Patient requesting for medical termination of pregnancy (mTOP)
* Patient eligible for legal abortion according to the Termination of Pregnancy Act (Chapter 324)
* Gestational age ≤10 weeks (on day 1 of mifepristone or letrozole administration) as confirmed by the first trimester dating scan
* Singleton pregnancy
* Patient is agreeable to undergo surgical evacuation or repeat medical therapy if treatment fails
* Willing and able to provide written, informed consent

Exclusion Criteria:

* History or evidence of adrenal pathology, steroid-dependent cancer, porphyria, poorly controlled hypertension, bronchial asthma, thromboembolism and severe cardiac/renal/liver disease
* Haemoglobin level of \<9.5 g/L
* Presence of an intrauterine contraceptive device
* Breastfeeding
* Reported allergic reaction to mifepristone, misoprostol or letrozole,
* Participating in another trial of investigational medicinal products during the current pregnancy

Where it's running

• KK Women's and Children's Hospital
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Meei Jiun Seet — Consultant at KK Women's and Children's Hospital, Singapore
• Study coordinator: Meei Jiun Seet
• Email: julin.wong.sx@kkh.com.sg
• Phone: (+65) 97865163

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• Misoprostol versus watchful waiting for retained tissue after first-trimester medical abortion

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.