Using laser treatment to prevent skin cancer in older adults with precancerous lesions
The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population
This study tests if a special laser treatment can help older adults with precancerous skin spots avoid developing skin cancer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Wright State University Academic / other |
| Locations | 1 site (Fairborn, Ohio) |
| Trial ID | NCT06428721 on ClinicalTrials.gov |
What this trial studies
This study investigates whether Fractionated Laser Resurfacing (FLR) can protect older adults with actinic keratosis (AKs) from developing skin cancer. Participants will have one forearm treated with FLR while the other forearm serves as a control. The study also aims to evaluate if skin photographs can predict the formation of AKs and skin cancers. The focus is on individuals aged 60 and older who have a specific number of AKs for monitoring purposes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 60 and older with 5 to 10 actinic keratoses on each forearm.
Not a fit: Patients with more than 10 actinic keratoses or those with significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce the risk of skin cancer in older adults with precancerous lesions.
How similar studies have performed: This approach builds on ongoing research at the Dayton Veterans Administration dermatology clinic, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult Males and Females aged 60 and older * Have at least 5 AKs on each forearm/wrist, but no more than 10 to allow for easy monitoring * Skin type fair (Fitzpatrick I-II) * Females must be post-menopausal and not be on systemic hormone replacement therapy * Able to comprehend procedures and risks Exclusion Criteria: * More than 10 AKs on an extremity * AKs that are large (2-3+, hyperkeratotic grade 3 lesions) * AKs that are very thick (\>3 mm) * Medical history of diabetes * History of poor wound healing or scarring * Large tattoos that can interfere with study * Other serious health issues and other skin diseases that could interfere with the study * Recent (within 1 year) field therapies such as efudex cream or PDT to forearms/wrists. * Planning to leave region in next 5 years * Subjects with allergies to xylocaine will be excluded if they need this topical anesthetic.
Where this trial is running
Fairborn, Ohio
- Wright State Physicians — Fairborn, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Jeffrey Travers, MD, PhD — Wright State University
- Study coordinator: Manager, Clinical Research Operations
- Email: pturesearch@wrightstatephysicians.org
- Phone: 937-245-7500
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.