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Clinical trial Recruiting at 1 site Interventional Ages 60 and up

Using laser treatment to prevent skin cancer in older adults with precancerous lesions

Official title: The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Run by Wright State University · NCT06428721 · Data updated 2026-11-12

This study tests if a special laser treatment can help older adults with precancerous skin spots avoid developing skin cancer.

More Aging trials

Quick facts

Study typeInterventional
Ages60 Years and up
SexAll
Enrollment80 (estimated)
SponsorWright State University
Academic / other
Locations1 site (Fairborn, Ohio)
StatusRecruiting
StartedMarch 20, 2024
Main results expectedDecember 2031
Study endsDecember 2031
Registry record updatedJuly 16, 2026
Trial IDNCT06428721 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 60 and older with 5 to 10 actinic keratoses on each forearm.

Probably not a fit

Patients with more than 10 actinic keratoses or those with significant health issues may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether Fractionated Laser Resurfacing (FLR) can protect older adults with actinic keratosis (AKs) from developing skin cancer. Participants will have one forearm treated with FLR while the other forearm serves as a control. The study also aims to evaluate if skin photographs can predict the formation of AKs and skin cancers. The focus is on individuals aged 60 and older who have a specific number of AKs for monitoring purposes.

Why it matters

Potential benefit: If successful, this treatment could significantly reduce the risk of skin cancer in older adults with precancerous lesions.

How similar studies have gone: This approach builds on ongoing research at the Dayton Veterans Administration dermatology clinic, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Adult Males and Females aged 60 and older
* Have at least 5 AKs on each forearm/wrist, but no more than 10 to allow for easy monitoring
* Skin type fair (Fitzpatrick I-II)
* Females must be post-menopausal and not be on systemic hormone replacement therapy
* Able to comprehend procedures and risks

Exclusion Criteria:

* More than 10 AKs on an extremity
* AKs that are large (2-3+, hyperkeratotic grade 3 lesions)
* AKs that are very thick (\>3 mm)
* Medical history of diabetes
* History of poor wound healing or scarring
* Large tattoos that can interfere with study
* Other serious health issues and other skin diseases that could interfere with the study
* Recent (within 1 year) field therapies such as efudex cream or PDT to forearms/wrists.
* Planning to leave region in next 5 years
* Subjects with allergies to xylocaine will be excluded if they need this topical anesthetic.

Where it's running

  • Wright State Physicians
    Fairborn, Ohio, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Actinic Keratoses 5Aging 2413Non-Melanoma Skin Cancer 6Wright State University 45
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.