Using larynx and vocal tract techniques to lower vocal fold contact pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will have adults (ages 18–40) with clinician-diagnosed phonotraumatic mid-membranous vocal fold lesions receive a standardized resonant voice therapy program. They will measure vocal fold contact pressure directly in vivo and use CT scans to compare laryngeal and vocal tract configurations before and after initial voice training. The team will relate immediate physical changes to perceptual, acoustic, and subglottic pressure measures and track patient-reported outcomes across longer-term therapy. Findings will test whether the physical adjustments predicted by prior simulations occur in people and whether early pressure reductions predict better therapy results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages 18-40 years (to minimize developmental changes associated with adolescent and elderly age)
* Clinic diagnosis by a fellowship trained laryngologist of mid-membranous lesions that by history and appearance are phonotraumatic
* Must be referred for voice therapy

Exclusion Criteria:

* Medical comorbidities (e.g., autoimmune disorders) beyond seasonal allergy and laryngopharyngeal reflux
* Vocal fold lesions generally regarded to be less responsive to voice therapy (e.g. vocal fold cysts).
* Claustrophobia
* Inability to replicate fundamental frequencies required for the study at the intensity levels determined

Where it's running

• UCLA Rehab Center
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Zhaoyan Zhang — University of California, Los Angeles
• Study coordinator: Zhaoyan Zhang
• Email: zyzhang@ucla.edu
• Phone: 3102064324

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.