Using L-PRF with a papilla preservation technique for treating periodontal defects
Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects: A Randomized Controlled Clinical Trial
This study is testing if using a special treatment called L-PRF along with a technique to save gum tissue can help people with gum disease heal better than those who don’t receive L-PRF.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universidad de los Andes, Chile Academic / other |
| Locations | 1 site (Santiago, San Bernardo) |
| Trial ID | NCT06694168 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of using leukocyte and platelet-rich fibrin (L-PRF) as a regenerative material alongside the entire papilla preservation (EPP) technique for treating interproximal intraosseous periodontal defects. The study will compare clinical and radiographic outcomes between patients treated with L-PRF and those treated without it. A total of 30 patients diagnosed with periodontal disease will be enrolled, and their postoperative complications and sensitivity will also be assessed. The goal is to determine if L-PRF enhances the treatment outcomes for patients with significant periodontal attachment loss.
Who should consider this trial
Good fit: Ideal candidates are patients diagnosed with periodontal disease who have residual probing depths of 6 mm or more after non-surgical therapy.
Not a fit: Patients with underlying health conditions such as uncontrolled diabetes, hypertension, or those on medications that affect healing may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve periodontal regeneration and enhance the quality of life for patients with severe periodontal disease.
How similar studies have performed: Previous studies have shown promising results with similar regenerative techniques, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with periodontal disease (loss of interproximal clinical attachment loss in 2 non-adjacent teeth or clinical attachment loss of ≥3mm associated with a PD \>3 mm in two or more teeth) will be included. * After re-evaluation (6 weeks after non-surgical periodontal therapy) presented residual probing depths equal to or greater than 6 mm. * Residual pocket is associated with interproximal intrabony periodontal defects of at least 2 walls, with a depth ≥ 3 mm and an angulation ≤ 40º determined on a periapical radiograph. Exclusion Criteria: * Patients with an underlying decompensated pathology such as diabetes and hypertension. * Patients taking medications that interfere with the healing process such as bisphosphonates. * Patients with diseases that alter bone metabolism such as osteoporosis. * Pregnant or breastfeeding women.
Where this trial is running
Santiago, San Bernardo
- CESA (centro de salud de la clínica odontológica de la Universidad de los Andes) — Santiago, San Bernardo, Chile (Recruiting)
Study contacts
- Principal investigator: Andreas G Anwandter, DDS — Universidad de Los Andes
- Study coordinator: Andreas G Anwandter, DDS
- Email: aanwandter@miuandes.cl
- Phone: +56225891100
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.