Using L-PRF to improve dental implant stability and bone levels
A Randomised Control Clinical Trial Investigating the Effect of L-PRF on Implant Stability and Marginal Bone Levels.
This study is testing if using a special treatment called L-PRF during dental implant surgery can help improve the stability of the implants and the surrounding bone for patients getting implants.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Dublin Dental University Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Dublin) |
| Trial ID | NCT06516263 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effect of leukocyte and platelet-rich fibrin (L-PRF) on the stability of dental implants and the levels of marginal bone surrounding them. The study focuses on achieving primary implant stability, which is crucial for successful osseointegration, by utilizing L-PRF during the implant placement procedure. Participants will be monitored for their healing process and the effectiveness of L-PRF in enhancing implant stability and bone integration. The trial is conducted at Dublin Dental University Hospital, where patients will receive standard implant placement alongside L-PRF treatment.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are scheduled for dental implants and have sufficient bone volume for placement.
Not a fit: Patients with high plaque or bleeding scores, uncontrolled systemic diseases, or those who smoke may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved dental implant success rates and better long-term outcomes for patients.
How similar studies have performed: Other studies have shown promising results with the use of L-PRF in dental procedures, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Inclusion Criteria: Patient Level * Male or Female, 18 years old or over * Capacity to provide informed consent * Willing to comply with study appointment schedule Willing to maintain a diary of symptoms * Planned for provision of dental implant(s) at Dublin Dental University Hospital Site Level * Location: maxilla and mandible * Sufficient bone volume for implant placement without the need for bone graft/augmentation; alveolar ridge of minimum 6mm width for standard implants (implant diameter 4mm) and of minimum 7mm for wider implants (implant diameter 5mm) Exclusion Criteria: * Patient Level * Plaque score \>20% * Bleeding score \>20% * Tobacco smoking * Uncontrolled systemic disease * Use of systemic medications with an expected impact on bone healing (e.g. bisphosphonates) * Pregnancy or lactation * lack of capacity to give informed consent * Previous radiation to the head and/or neck Site Level * Insufficient bone volume for implant placement, requiring bone graft/augmentation
Where this trial is running
Dublin
- Dublin Dental University Hospital — Dublin, Ireland (Recruiting)
Study contacts
- Study coordinator: Daniel Merrick, BDent Sc
- Email: merrickd@tcd.ie
- Phone: 00353877410480
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.