Using L-PRF Block in Endodontic Microsurgery
Endodontic Microsurgery With the Use of L-PRF Block: a Randomized Controlled Clinical Trial
This study tests if using a special treatment called L-PRF Block during endodontic microsurgery helps patients with large tooth infections feel better and heal faster compared to standard care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Leuven, Vlaams-Brabant) |
| Trial ID | NCT05379010 on ClinicalTrials.gov |
What this trial studies
This study evaluates the impact of leucocyte and platelet rich fibrin Block (L-PRF Block) on post-operative comfort and bone healing in patients undergoing endodontic microsurgery for large peri-apical lesions. It is designed as an open randomized controlled trial with two groups: one receiving the L-PRF Block during the procedure and the other receiving standard care without it. The aim is to determine whether the addition of L-PRF Block improves outcomes for patients with significant periapical lesions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who require endodontic microsurgery for large periapical lesions.
Not a fit: Patients who are not suitable for endodontic microsurgery or have significant systemic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance patient comfort and promote better healing of bone tissue after endodontic procedures.
How similar studies have performed: While the use of L-PRF in various surgical contexts has shown promise, this specific application in endodontic microsurgery is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Provision of Informed Consent * Patients from 18 years old * Patients in need of an EMS * EMS is the only option to cure the periapical lesion * A periapical lesion that has a diameter of 10mm or more in sagittal plane, frontal plane or axial plane when measured on CBCT Exclusion Criteria * Unlikely to be able to comply with the study procedures, as judged by the investigator * Orthograde endodontic (re)treatment is indicated * Known or suspected current malignancy * History of chemotherapy within 5 years prior to study * History of radiation in the head and neck region * History of other metabolic bone diseases * History of bleeding disorders * HIV disease * Hepatitis B or C * Systemic disease (osteoporosis, diabetes...)
Where this trial is running
Leuven, Vlaams-Brabant
- UZ Leuven — Leuven, Vlaams-Brabant, Belgium (Recruiting)
Study contacts
- Principal investigator: Nastaran Meschi, DDS — UZ Leuven
- Study coordinator: Nastaran Meschi, PhD
- Email: Nastaran.meschi@kuleuven.be
- Phone: 0032476313889
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.