Using L-PRF and Nanohydroxyapatite for treating irreversible pulpitis in molars
Clinical and Radiographic Assessment of L-PRF, Nanohydroxyapatite Material Combined With L-PRF Scaffold in Vital Pulp Therapy. Treatments in Mandibular First Molars With Closed Apices "Randomized Controlled Trial"
This study tests whether using L-PRF, nanohydroxyapatite, or a mix of both can help save the teeth of people with irreversible pulpitis in their molars.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Ages | 15 Years to 30 Years |
| Sex | All |
| Sponsor | Future University in Egypt Academic / other |
| Locations | 1 site (Cairo, New Cairo) |
| Trial ID | NCT06613932 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of L-PRF and nanohydroxyapatite in pulpotomy procedures for mature mandibular first molars diagnosed with irreversible pulpitis. Participants are randomly assigned to three groups: one receiving hydroxyapatite, another receiving L-PRF, and a third receiving a combination of both materials. The study aims to assess clinical outcomes and radiographic results over a follow-up period. The goal is to determine which treatment provides the best results for preserving tooth vitality.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals aged 15-30 with signs of irreversible pulpitis in mature mandibular first molars.
Not a fit: Patients with systemic diseases, immature roots, or necrotic pulp will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve treatment outcomes for patients with irreversible pulpitis, potentially preserving their natural teeth.
How similar studies have performed: While there is limited data on the combined use of L-PRF and nanohydroxyapatite, similar approaches in pulp therapy have shown promising results in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: Patients should be free from any systemic disease. Patients of either gender aged from 15-30. Patients will agree to the consent and will commit to a follow-up period. Soft tissues around the tooth are normal with no swelling or sinus tract. The tooth is restorable tooth has signs and symptoms of irreversible pulpitis of the mature root The tooth doesn\'t contain any internal or external resorption or periapical lesions. The tooth should give a positive response to the cold test. Exclusion criteria: Pregnant and lactating females. Patients with Mental disturbance. Patients who could/would not participate in a 6-month follow-up. A tooth with immature roots. Patients with necrotic pulp.• tooth with periapical lesions or infections. Soft tissue having fistula or swelling Homoeostasis after 10 minutes can not be controlled after total pulpotomy
Where this trial is running
Cairo, New Cairo
- future university in Egypt — Cairo, New Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: nada A metwally, master
- Email: nadaaymaan55@gmail.com
- Phone: 01122289353
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.