Using ketamine for sedation to protect the brain after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of ketamine as a sedative in patients who have experienced out-of-hospital cardiac arrest (OHCA) to determine its neuroprotective effects compared to the standard sedative, propofol. The study focuses on adults who have been resuscitated from OHCA with a shockable heart rhythm and aims to assess the impact of ketamine on neuronal damage markers and long-term neurological outcomes. By evaluating the potential benefits of ketamine in this critical setting, the trial seeks to improve the prognosis for OHCA survivors who are at risk of hypoxic-ischemic brain injury.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (age ≥18 years) AND
* resuscitated OHCA of presumed cardiac cause with a shockable first recorded heart rhythm AND
* mean arterial pressure (MAP) \>40 mmHg AND
* a decision to perform prehospital intubation.

Exclusion Criteria:

* Advanced life support termination-of-resuscitation (TOR) criteria met
* Systolic blood pressure \>190 mmHg
* Known allergy to ketamine or propofol
* Chronic diseases making 180-day survival unlikely
* Body temperature \<30° C.

Where it's running

• Department of Cardiology, Rigshospitalet
  Copenhagen, Denmark Recruiting
• Odense University Hospital
  Odense C, Denmark Not yet recruiting

Study contacts

• Study coordinator: Salma Charabi, MD
• Email: salma.charabi@regionh.dk
• Phone: 35450572

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.