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Using Ixazomib with Stem Cell Transplant for Relapsed Myeloma

A Phase III Study to Determine the Role of Ixazomib as an Augmented Conditioning Therapy in Salvage Autologous Stem Cell Transplant (ASCT) and as a Post-ASCT Consolidation and Maintenance Strategy in Patients With Relapsed Multiple Myeloma

Phase 3 Interventional University of Leeds · NCT03562169

This study is testing if adding ixazomib to the usual stem cell transplant treatment can help people with relapsed multiple myeloma feel better and live longer.

Quick facts

PhasePhase 3
Study typeInterventional
Enrollment406 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Leeds Academic / other
Drugs / interventionschemotherapy, radiation
Locations91 sites (Aberdeen and 90 other locations)
Trial IDNCT03562169 on ClinicalTrials.gov

What this trial studies

This phase III clinical trial investigates the effectiveness of ixazomib, a proteasome inhibitor, in combination with thalidomide and dexamethasone during the re-induction phase for patients with relapsed multiple myeloma. The study aims to compare the outcomes of conventional autologous stem cell transplant (ASCT) versus an augmented ASCT approach, assessing various response metrics, overall survival, and quality of life. Participants will be monitored for response durability and safety throughout the treatment process.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with relapsed multiple myeloma who have previously undergone autologous stem cell transplant and meet specific health criteria.

Not a fit: Patients who have not experienced a relapse after their first autologous stem cell transplant or those with severe comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could improve treatment outcomes and prolong survival for patients with relapsed multiple myeloma.

How similar studies have performed: Previous studies have shown promising results with proteasome inhibitors in multiple myeloma, indicating potential for success with this novel combination approach.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Diagnosed with relapsed MM (with measurable disease, according to IMWG criteria (Appendix 2)) previously treated with ASCT).
2. First Progressive Disease (PD) at least 12 months following first ASCT, requiring therapy.
3. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2 (Appendix 3).
4. Aged at least 18 years.
5. Participants must have the following blood results within 14 days before registration:

   1. Absolute neutrophil count (ANC) ≥1x109/L
   2. Platelet count ≥75x109/L. If the participant has ≥50% bone marrow infiltration a platelet count of ≥50x109/L is allowed.

   Platelet transfusions are not allowed within 3 days before registration in order to meet these values.
6. Adequate renal function within 14 days before registration:

   a. Creatinine clearance ≥30ml/min (calculated according to the Cockcroft-Gault equation or other locally approved formula)
7. Adequate hepatobiliary function within 14 days before registration:

   1. Total bilirubin \<2 x upper limit of normal (ULN)
   2. ALT \<2 x ULN
8. Adequate pulmonary function within 14 days before registration:

   a. Adequate respiratory functional reserve (delineated by KCO/DLCO (carbon monoxide diffusion in the lung) of ≥50%). No evidence of a history of pulmonary disease. If a significant history, then a review by a respiratory medicine physician is required.
9. Adequate cardiac function within 12 weeks before registration

   a. Left ventricular ejection fraction (LVEF) ≥40%. Note: repeat confirmation of cardiac function is needed if treatment is given between this assessment and registration.
10. Female participants who:

    1. Are not of childbearing potential (Appendix 8), OR
    2. If they are of childbearing potential (Appendix 8), agree to practice 2 effective methods of contraception (Appendix 8), at the same time, from the time of signing the informed consent form until 90 days after the last dose of study drug, OR
    3. Agree to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. (Periodic abstinence \[e.g. calendar, ovulation, symptothermal, post-ovulation methods\] and withdrawal are not acceptable methods of contraception.)

    Male participants, even if surgically sterilised (i.e. status post-vasectomy), must agree to one of the following:
    1. Agree to practice effective barrier contraception during the entire study treatment period and through 90 days after the last dose of study drug, OR
    2. Agree to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. (Periodic abstinence (e.g. calendar, ovulation, symptothermal, post-ovulation methods\] and withdrawal are not acceptable methods of contraception.) Contraception for female and male participants must be in accordance with (and consent to) the Celgene-approved Thalidomide Pregnancy Prevention Programme.
11. If female and of childbearing potential (see Appendix 8), must have a negative pregnancy test performed by a healthcare professional in accordance with the Celgene Thalidomide Pregnancy Prevention Programme.
12. Patients agree not to receive other clinical trials treatment, including investigational medicinal products (IMPs) not included in this trial, within 30 days of trial registration and throughout the duration of the trial, until disease progression.
13. Able to provide written informed consent.

Exclusion Criteria:

1. Received prior second line therapy for their relapsed disease other than local radiotherapy, therapeutic plasma exchange, or dexamethasone (up to a maximum of 200mg is allowed but not within 30 days prior to registration). Radiotherapy sufficient to alleviate or control pain of local invasion is permitted, but must not be within 14 days before registration. Patients who have received hemi-body radiation or similar since relapse will not be eligible.
2. ≥Grade 2 peripheral neuropathy within 14 days before registration.
3. Known HIV seropositivity.
4. Known resistance, intolerance or sensitivity to any component of the planned therapies.
5. Any medical or psychiatric condition which, in the opinion of the investigator, contraindicates the participant's participation in this study.
6. Previous or concurrent malignancies at other sites (excluding completely resected non-melanoma skin cancer or carcinoma in situ of any type, such as cervical cancer).
7. Pregnant, lactating or breast feeding female participants.
8. Failure to have fully recovered (i.e.Grade 1 or less toxicity) from the reversible effects of prior chemotherapy.
9. Major surgery within 14 days before registration.
10. Central nervous system involvement with myeloma.
11. Ongoing or active infection requiring systemic antibiotic therapy or other serious infection within 14 days before registration.
12. Evidence of current uncontrolled cardiovascular conditions, including uncontrolled hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure, unstable angina, or myocardial infarction within the past 6 months.
13. Systemic treatment, within 14 days before the first dose of ixazomib with strong CYP3A inducers (e.g. rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital), or use of Ginkgo biloba or St. John's wort.
14. Known gastrointestinal (GI) disease or GI procedure that could interfere with the oral absorption or tolerance of ixazomib, including difficulty swallowing.
15. Patients that have previously been treated with ixazomib or participated in a study with ixazomib whether treated with ixazomib or not.
16. Participant has current or prior hepatitis B or C infection.

Where this trial is running

Aberdeen and 90 other locations

+41 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Multiple Myeloma
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.