Using IVUS to guide stent placement in patients with coronary calcification

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of intravascular ultrasound (IVUS) to guide the implantation of drug-eluting stents (DES) in patients with severe coronary calcification. It aims to determine whether IVUS guidance can improve clinical outcomes compared to traditional angiography guidance in this specific patient population. The study will include patients with various forms of coronary artery disease, particularly those with calcified lesions that are eligible for stent placement. The findings could provide valuable insights into the effectiveness of IVUS in enhancing procedural success and patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Silent ischemia, stable or unstable angina, non-ST-segment elevation myocardial infarction \> 48 hours, or ST-segment elevation myocardial infarction \> 7 days;
2. De novo coronary lesion eligible for drug-eluting stent implantation;
3. Target lesion with severe calcification;

Exclusion Criteria:

1. Age less than 18-year-old;
2. Comorbidity with a life expectancy \<12 months;
3. Intolerant of antithrombotic therapy;
4. Significant anemia, thrombocytopenia, or leucopenia;
5. History of major hemorrhage (intracranial, gastrointestinal, and so on);
6. Chronic total occlusion lesion not recanalized;
7. Scheduled major surgery in the next 12 months;
8. Left ventricular ejection fraction \< 25%;
9. Uremia dependent on dialysis treatment;
10. Previous drug-eluting stent implantation in target vessel;

Where it's running

• Nanjing First Hospital
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Shao-Liang Chen, MD — The First Affiliated Hospital with Nanjing Medical University
• Study coordinator: Jun-Jie Zhang, MD
• Email: jameszll@163.com
• Phone: 025-52271350

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.