Using ischemic postconditioning to improve outcomes in heart attack patients
Official title: The Effect of Ischemic Postconditioning in Patients With STEMI Undergoing Primary PCI (DANAMI4-iPOST2)
Run by Copenhagen University Hospital, Rigshospitalet · NCT03787745 · Data updated 2026-11-12
This study is testing if a new method called ischemic postconditioning can help heart attack patients recover better and reduce the risk of heart failure after treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1800 (estimated) |
| Sponsor | Copenhagen University Hospital, Rigshospitalet Academic / other |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | February 4, 2019 |
| Main results expected | May 31, 2026 |
| Study ends | January 31, 2033 |
| Registry record updated | March 30, 2026 |
| Trial ID | NCT03787745 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who present with acute chest pain and have a confirmed diagnosis of STEMI with TIMI flow 0-1.
✕Probably not a fit
Patients who are pregnant, have experienced out-of-hospital cardiac arrest without regaining consciousness, or require thrombectomy are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The iPOST2 trial is a prospective, randomized clinical trial aimed at determining whether ischemic postconditioning can reduce reperfusion injury and improve clinical outcomes in patients with ST Segment Elevation Myocardial Infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). This approach involves repetitive interruptions of blood flow to the injured heart region after initial reperfusion. The trial specifically excludes patients who undergo thrombectomy, as previous studies indicated that this may interfere with the benefits of postconditioning. By focusing on patients with TIMI flow 0-1, the study seeks to provide clearer insights into the effectiveness of ischemic postconditioning in reducing heart failure and mortality rates.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the rates of heart failure and death in STEMI patients.
How similar studies have gone: While previous studies like DANAMI3-iPOST did not show significant benefits, the iPOST2 trial aims to clarify the effectiveness of ischemic postconditioning without thrombectomy, making it a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Acute onset of chest pain with \< 12 hours duration * STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI. * TIMI flow 0-1 in infarct related artery Exclusion Criteria: * Potential pregnancy * Refusal to participate * OHCA without subsequent consciousness despite ROSC * Thrombectomy considered unavoidable
Where it's running
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The Heart Center, Rigshospitalet, University of Copenhagen
Copenhagen, Denmark Recruiting
Study contacts
- Study coordinator: Thomas Engstrøm, DMSci
- Email: thomas.engstroem@regionh.dk
- Phone: +4535458444
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Biomarkers to predict no-reflow after opening the heart’s artery in STEMI patients
This study tests whether immune-inflammatory and metabolic biomarkers can predict coronary no-reflow after primary PCI in adults with STEMI.
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Thrombus removal during PCI after thrombolysis for STEMI
This trial will test whether removing clots during PCI improves outcomes for people with STEMI who received thrombolysis and have a high thrombus burden.
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FAST-guided PCI in STEMI with Multivessel Disease
This trial tests whether using the FAST technique during PCI in STEMI patients with multivessel disease improves outcomes compared with standard treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.