Using Iodine-124 PET scans to assess metastatic thyroid cancer treatment
Official title: Lesion Dosimetry With Iodine-124 in Metastatic Thyroid Carcinoma
Run by Memorial Sloan Kettering Cancer Center · NCT03647358 · Data updated 2026-11-12
This study is testing a new type of PET scan using iodine-124 to see how well it can help doctors decide on the best treatment for people with metastatic thyroid cancer.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | August 21, 2018 |
| Main results expected | August 2027 |
| Study ends | August 2027 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT03647358 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults with confirmed metastatic thyroid carcinoma who have undergone total thyroidectomy and are planning to receive radioiodine therapy.
✕Probably not a fit
Patients under 18 years old or those who are pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates a new diagnostic imaging test using positron emission tomography (PET) with iodine-124 to measure radioactive iodine uptake in metastatic thyroid carcinoma. If the test indicates sufficient uptake, standard treatment with radioiodine will continue; if not, alternative therapies may be considered. The study aims to improve treatment decisions for patients with thyroid cancer by providing more accurate dosimetry information. Participants will undergo PET/CT scans to assess their condition before therapy.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized and effective treatment strategies for patients with metastatic thyroid carcinoma.
How similar studies have gone: Other studies using similar imaging techniques have shown promise, but this specific approach with iodine-124 is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults with thyroid carcinoma confirmed by pathology. * Adult thyroid carcinoma patients who have undergone total thyroidectomy * Adult thyroid carcinoma patients have metastatic disease or suspicion for metastatic disease, or are under a protocol intended to explore re-induction therapy for 131I uptake, and are about to undergo Thyrogen-assisted dosimetry, unless Thyrogen-assisted dosimetry is not required per standard of care. * The patient and physician are planning to administer 131I for therapy if persistent radioiodine-avid metastases are present. * All subjects must have measurable disease, documented within the previous six months by ultrasonography (US), MRI, FDG PET/CT, or CT scanning. Exclusion Criteria: * Age less than 18 years. * Patients who are pregnant.
Where it's running
-
Memorial Sloan Kettering Cancer Center
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Ravinder Grewal, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Ravinder Grewal, MD
- Email: grewalr@mskcc.org
- Phone: 212-639-2872
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.