Using intravenous albumin to prevent worsening kidney function in heart failure patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of intravenous human albumin in patients hospitalized for acute decompensation of chronic heart failure (CHF) who also exhibit signs of hepatic dysfunction. The study aims to determine if combining albumin with loop diuretics can improve diuretic efficacy and protect against worsening renal function, which is a common complication in these patients. Participants will be monitored for their response to treatment over a period of at least 72 hours. The trial focuses on a specific subgroup of CHF patients who may be particularly vulnerable to renal issues due to their liver condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age over 18 yrs
2. acute decompensation of CHF
3. evidence of hepatic dysfunction by laboratory biochemical measurements or imaging (liver ultrasonography)
4. history of CHF with previous use of an oral loop diuretic
5. anticipated need for IV diuretic therapy for at least 72 hours

There is no pre-specified inclusion criterion with respect to ejection fraction

Exclusion Criteria:

1. hemodynamic collapse (at least one of the following: systolic blood pressure (BP) \< 90 mmHg, or BP drop by \>= 40 mmHg for \>= 15 min, with end-organ hypoperfusion; need for inotropes (except of digoxin); need for cardiopulmonary resuscitation).
2. hepatic dysfunction of other than cardiac etiology
3. severe anemia (Hb\<8 g/dL)
4. uncontrolled hypertension or hypertensive emergency/urgency
5. pulmonary edema or pulmonary congestion necessitating use of IV vasodilators
6. serum creatinine \> 3 mg/dL or glomerular filtration rate (GFR) \< 30 ml/min

Where it's running

• DUThrace Cardiology Department
  Alexandroupoli, Evros, Greece Recruiting

Study contacts

• Principal investigator: Marios Vasileios Koutroulos — University Hospital of Alexandroupolis
• Study coordinator: Marios-Vasileios a Koutroulos
• Email: mvkoutroulos@gmail.com
• Phone: +30 6942862493

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.