Using intracranial EEG to locate areas causing epilepsy and assess prognosis
The Role of IEEG in the Localization of EZ and Its Relationship With Prognosis
This study is testing how using special brain monitoring can help find the exact areas causing seizures in people with hard-to-treat epilepsy to improve their chances of successful surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 3 Years to 70 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou) |
| Trial ID | NCT05443958 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of intracranial electroencephalography (iEEG) in accurately identifying the epileptogenic zones in patients with drug-resistant epilepsy. By monitoring patients with habitual seizures, the study aims to analyze the local cortical electrical activity and its relationship with surgical outcomes. The goal is to improve the understanding of seizure localization and enhance the effectiveness of surgical interventions for epilepsy. Participants will be followed for at least one year to evaluate the long-term prognosis post-surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with drug-resistant epilepsy who have undergone iEEG monitoring and experienced at least one habitual seizure.
Not a fit: Patients who do not have habitual seizures detected during iEEG monitoring or those who do not undergo surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical outcomes for patients with drug-resistant epilepsy by providing more accurate localization of seizure-causing areas.
How similar studies have performed: Other studies have shown that iEEG is a reliable method for localizing epileptogenic zones, suggesting that this approach has potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Complete clinical history; 2. IEEG monitoring at least one habitual seizure； 3. Follow up for at least 1 year； 4. Signed informed consent. Exclusion Criteria: 1. Habitual seizures were not found in iEEG monitoring; 2. No operation was performed; 3. Lost to follow-up for various reasons within 1 year after surgery.
Where this trial is running
Hangzhou
- 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China — Hangzhou, China (Recruiting)
Study contacts
- Study coordinator: Lingli Hu, Master
- Email: hulingli21@163.com
- Phone: 18613040114
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.