Using intermittent theta burst stimulation to treat fibromyalgia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of intermittent theta burst stimulation (iTBS), a form of repetitive transcranial magnetic stimulation (rTMS), on patients diagnosed with fibromyalgia syndrome. It aims to include at least 30 participants aged 18-65 who have been experiencing chronic pain and other symptoms associated with fibromyalgia. The study will compare the effects of active iTBS treatment against a sham treatment to evaluate its efficacy in pain relief and symptom management. The research is being conducted at İzmir Katip Çelebi University Atatürk Training and Research Hospital, focusing on a population that has stable fibromyalgia treatment for the past three months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Being between the ages of 18-65
* Being diagnosed with fibromyalgia syndrome (according to 2016 criteria)
* Average pain intensity of NRS ≥ 4/10
* Fibromyalgia treatment was stable for the last 3 months and no treatment change was planned during the study

Exclusion Criteria:

* Having a clinical condition that would constitute a contraindication for TMS (metallic implant, cardiac pacing, pregnancy, epilepsy, head trauma, history of cranial operation...)
* Presence of malignancy
* Systemic rheumatologic diseases
* Major orthopedic problems limiting activities of daily living (gait disturbance or fracture sequelae limiting joint mobility, prostheses, nerve-tendon injuries)
* Serious neurological diseases (increased intracranial pressure, presence of space-occupying lesions in the brain, history of epilepsy, presence of cerebral aneurysm, Parkinson's disease, Huntington's chorea, multiple sclerosis, history of previous head trauma causing loss of consciousness)
* Alcohol or drug addiction
* History of major depression/personality disorder or psychosis
* Having received TMS treatment before
* Taking benzodiazepine, gabapentin/pregabalin or anticonvulsant medications that have the potential to interfere with intermittent theta burst stimulation treatment or have taken them within the last 4 weeks
* Pregnant or planning pregnancy or breastfeeding

Where it's running

• Izmir Katip Çelebi University Atatürk Training and Research Hospital
  Izmir, Karabaglar, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ayhan ASKIN, Professor
• Email: ayhan.askin@ikc.edu.tr
• Phone: 902322444444

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.