Using inhaled nitroglycerin to improve breathing in late-stage COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of nebulized nitroglycerin on respiratory function in patients with late-stage Chronic Obstructive Pulmonary Disease (COPD). The approach focuses on the vasodilation of pulmonary arteries and arterioles, which can alleviate ventilation/perfusion mismatching that exacerbates COPD symptoms. Additionally, the study aims to enhance antibiotic delivery to the alveoli, potentially improving infection control in these patients. It is designed as an interventional study, encompassing both Phase 2 and Phase 3 evaluations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient's ≥ 18 years old COPD exacerbation with respiratory failure and Echo evidenced presence of pulmonary hypertension (defined as mean pulmonary artery pressure \> 20 mmHg)

Exclusion Criteria:

* Profound left ventricular failure, as the decrease in pulmonary vascular resistance results in an increase in left ventricular preload. This may worsen cardiogenic pulmonary edema.
* Pregnant female patients
* Patient with hypersensitivity to nitroglycerin

Where it's running

• Haram Hospital
  Haram, Giza Governorate, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.