Using inhaled gases for advanced lung MRI imaging
Development of Hardware and Software for Pulmonary Magnetic Resonance Imaging Using Inhaled Tracer Gases
The Hospital for Sick Children · NCT04726618
This study is testing if inhaling special gases can help create better lung images using MRI for healthy people aged 6 to 75.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 6 Years to 75 Years |
| Sex | All |
| Sponsor | The Hospital for Sick Children (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT04726618 on ClinicalTrials.gov |
What this trial studies
This observational study aims to develop hardware and software for pulmonary magnetic resonance imaging (MRI) using inhaled tracer gases like hyperpolarized xenon and perfluoropropane. The study hypothesizes that these gases can enhance the quality of lung function images compared to conventional MRI techniques. By utilizing non-invasive imaging methods, the study seeks to provide detailed functional and structural information about the lungs without the risks associated with ionizing radiation. The research is conducted at a single center, focusing on healthy volunteers aged 6 to 75 years.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy individuals aged 6 to 75 who meet MRI screening criteria.
Not a fit: Patients with existing pulmonary diseases or those requiring supplemental oxygen will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved diagnostic capabilities for respiratory diseases without exposing patients to harmful radiation.
How similar studies have performed: While the use of inhaled tracer gases in MRI is a novel approach, similar imaging techniques have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Consent provided * Aged 6-75 years old * In good general health as evidenced by medical history * Meets MRI screening criteria Exclusion Criteria: * Has diagnosis of pulmonary disease * FEV1 \<70% * Requires supplemental oxygen * Has had a respiratory infection within the past 2 weeks * Pregnant or lactating\*
Where this trial is running
Toronto, Ontario
- Hospital for Sick Children — Toronto, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Giles Santyr, PhD — The Hospital for Sick Children
- Study coordinator: Giles Santyr, PhD
- Email: giles.santyr@sickkids.ca
- Phone: 416-813-7654
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy Volunteers, Lung MRI, Healthy, HP Xenon gas, Perfluoropropane gas