Using inflammation tests to improve asthma diagnosis in children and adults
PROPULSION SANTE: Inflammometry to Improve the Diagnostic Trajectory in Situations of Suspected Asthma in Children and Adults
This study is testing if measuring certain inflammation markers can help doctors diagnose asthma faster in children and adults who are suspected of having the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1500 (estimated) |
| Ages | 6 Years and up |
| Sex | All |
| Sponsor | Université de Sherbrooke Academic / other |
| Locations | 3 sites (Montreal, Quebec and 2 other locations) |
| Trial ID | NCT06981169 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of inflammometry, specifically measuring fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC), in prioritizing respiratory diagnostic tests for suspected asthma cases. It will include patients aged six and older who have been referred for diagnostic asthma testing at three hospital centers in Quebec. The hypothesis is that utilizing these biomarkers will reduce diagnostic delays for high-risk patients, thereby improving the overall diagnostic pathway and reducing wait times for necessary tests. The study seeks to address the current challenges in accessing timely asthma diagnostics, particularly for those with Type 2 eosinophilic inflammation.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged six and older who have been referred by primary care for asthma diagnostic testing.
Not a fit: Patients referred by pulmonologists will not benefit from this study as they do not meet the inclusion criteria.
Why it matters
Potential benefit: If successful, this approach could significantly shorten wait times for asthma diagnosis and improve patient outcomes by facilitating timely treatment.
How similar studies have performed: While the use of FeNO as a diagnostic tool is established in Europe, this specific approach in Quebec is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients age 6 and older * referred by primary care ofr an asthma diagnostic test (spirometry or methacholine challenge) Exclusion Criteria: * referred by pulmonologist
Where this trial is running
Montreal, Quebec and 2 other locations
- CHU Sainte-Justine — Montreal, Quebec, Canada (Not_yet_recruiting)
- Montreal Children's Hospital — Montreal, Quebec, Canada (Not_yet_recruiting)
- CIUSSS de l'Estrie - CHUS — Sherbrooke, Quebec, Canada (Recruiting)
Study contacts
- Study coordinator: Simon Couillard, MD, MSc
- Email: s.couillard@usherbrooke.ca
- Phone: +1-819-346-1110
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.