Using Indomethacin to Treat Acute Pancreatitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effectiveness of rectal indomethacin as an early treatment for acute pancreatitis, a condition characterized by inflammation of the pancreas. Patients aged 18-80 diagnosed with acute pancreatitis will be randomly assigned to receive either indomethacin or a placebo. The study aims to assess the impact of indomethacin on reducing complications and mortality rates associated with acute pancreatitis. The trial seeks to fill the gap in high-quality evidence regarding the use of NSAIDs in treating this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients ages 18-80 years with a diagnosis of AP based on at least 2 of the following criteria:
* Abdominal pain characteristic of AP
* Serum amylase and/or lipase ≥ 3 times the upper limit of normal
* Characteristic findings of AP on abdominal CT scan will be screened for study enrollment.

Exclusion Criteria:

* Onset time \>24 hours
* Presence of renal dysfunction (serum creatinine \> 1.5 \*normal upper limit)
* Severe liver dysfunction
* Active peptic ulcer disease or GI bleeding
* Pregnancy or breast-feeding
* Hypersensitivity to NSAIDs
* New-onset, exacerbation or uncontrolled hypertension
* Presence of serious cardiovascular events, including severe heart failure, myocardial infarction (MI) and stroke
* Mental disability
* Malignancy-associated acute pancreatitis
* Post-ERCP pancreatitis
* Informed consent not signed

Where it's running

• Peking University Sixth Hospital
  Beijing, Beijing Municipality, China Recruiting
• Peking Union Medical College Hospital
  Beijing, Beijing Municipality, China Recruiting
• Liangxiang Hospital
  Beijing, Beijing Municipality, China Recruiting
• Guiyang Second People's Hospital
  Guiyang, Guizhou, China Recruiting
• Baoding Seventh Hospital
  Baoding, Hebei, China Recruiting
• Fourth Affiliated Hospital of Harbin Medical University
  Harbin, Heilongjiang, China Recruiting

Study contacts

• Principal investigator: Zhitao Lu, M.D. — Baoding Seventh Hospital
• Study coordinator: Dong Wu, M.D.
• Email: dongwu@pumc.edu.cn
• Phone: 8618612671010

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Fecal microbiota transplant to prevent infections after late-phase severe acute pancreatitis

  This trial will test whether giving healthy donor gut bacteria (fecal microbiota transplantation) through a feeding tube in the late phase of moderately severe or severe acute pancreatitis can prevent infectious complications.

  Recruiting Changhai Hospital · Fuzhou, Fujian and 11 other locations · NCT07464392

• How often splanchnic vein clots occur in acute pancreatitis and whether they relate to disease severity

  This project will see if people with acute pancreatitis develop blood clots in the splenic, portal, or superior mesenteric veins and whether those clots are linked to more severe illness.

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• Sivelestat treatment to protect organs after surgery for type A aortic dissection

  In this multicenter trial, patients after surgery for type A aortic dissection receive sivelestat or a placebo to see if it helps protect organ function.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.